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Risperidone 조기 중단군 및 장기 유지군의 임상적 특성 비교
김광수,박원명,전태연,배치운,김대진,백인호,이철,김정수,한상익,최보문,장계호,고효진 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3
연구목적 : Risperidone 투여후 조기 중단한 환자들과 장기적으로 계속 risperidone을 복용하고 있는 환자의 임상적 특성을 평가하고 나아가 risperidone장기 유지와 조기 중단의 요인을 분석하고 정신병리가 약물 투여에 미치는 영향을 조사하고자 하였다. 방 법 : 연구 대상자는 1996년 1월부터 1996년 12월까지 가톨릭대학교 의과대학 부속 8개 병원 정신과에서 risperidone을 투여 시작한 환자 580명중 DSM-IV기준에 의해 정신분열병으로 진단받고 투여 기간이 6개월 미만(조기 중단군)이거나 2년 이상(장기 유지군)을 경과하였으며 의무기록의 누락이 없는 210명을 선정하였다. 두 군간 임상적 특성을 조사하기 위하여 인구학적 변인, 정신병리학적 변인, 약물 투여기록 및 부작용 등을 과거 의무기록을 근거로 평가하였다. 결 과 : 대상환자 210명 중 조기 중단군이 67명(31.9%)이었고 장기 유지군은 143명(68.1%)이었으며 두 군간 인구학적 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 변인과 정신병리학적 변인에 따른 특징에는 두 군간 차이가 없었다. 두 군간 risperidone의 시작 용량과 최대 용량은 유의한 차이가 없었으나 유지용량은 조기 중단군에서 4.49(±1.44)mg,장기 유지군에서 3.67(±1.50)mg으로 유의한 차이가 있었다(t=3.698, p<0.05). 또한, 이전 항정신병약물의 사용 기왕력 변인에서 조기 중단군은 기왕력이 없는 환자가 39명(58.2%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 27명(40.3%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 1명(1.5%)이었고, 장기 유지군은 기왕력이 없는 환자가 58명(40.6%), 고역가 항정신병약물을 사용한 기왕력이 있는 환자는 77명(53.8%), 저역가 항정신병약물을 사용한 기왕력이 있는 환자는 8명(5.6%)으로 유의한 차이가 있었다.(x²=6.559, df-=2, p<0.05). 결 론 : 본 연구결과에 의하면 가급적 환자 상태에 따라 낮은 최적 치료 용량을 투여하는 것이 장기잔의 투여를 바람직한 것으로 생각된다. 본 연구와 같은 대규모의 후향적 자연적 연구는 일반 실제 진료에서 risperidone의 효과 및 기타 다른 측면에서의 유용한 정보를 얻을 것으로 기대된다. Objective : This retrospective naturalistic study was designed to compare the clinical characteristics including psychopathology of two groups of patients, long-term maintenance group and short-term drop-out group, who were taking risperidone. Method : Datas were collected for 210 schizophrenic patients with complete medical records among 580 patients who were enrolled with risperidone administration from January 1996 to December 1996 in 8 affiliated hospital of the Catholic University. The short-term drop-out patients group were assigned to whom treatment period was less than 6 month, and the long-term maintained patients group, treatment period was more than 2 years. We assessed demographics, psychopathology, and other variables related with medication based on past medical records. Results : Among subjects of 210, short-term drop-out patients group were 67(31.9%) and long-term maintained patients group were 143(68.1%). Demographics and psychopathology were not significantly different between two groups. The stating and maximal dosage of risperidone was not significantly different between two groups but the maintenance dosage of risperidone was lower in long-term medicated patients group than short-term drop-out patients group(t=3.698, p<0.05). Additionally, the result of this study showed differences in experiences of past antipsychotic use as following. The number of no previous use of antipsychotic was 39(58.2%), the number of high potency amtipsychotic use was 27(40.3%), and the number of no previous use of antipsychotic was 58(40.6%), the number of high potency ntipsychotic use was 77(53.8%), the number of low potency antipsychotic use was8(5.6%) in long-term maintained group.(x²=6.559, df-=2, p<0.05). Conclusions : According to these results, administration of low therapeutic dosage should be recommended for long-term maintenance as if possible. Multi-center based retrospective naturalistic study like this would be useful for getting informations about efficacy and some other aspects of antipsychotic administration in practial field.
Si Bulk Micromachining을 위한 Wafer Rolling Etching 및 그 특성
김건년,이보나,박효덕,신상모,공경준,장동근,김병철,권혁채,이봉희 경북대학교 센서기술연구소 1998 센서技術學術大會論文集 Vol.9 No.1
A wafer rolling etching system for the silicon bulk micromachining has been designed and fabricated. The silicon diaphragms were anisotropically etched in a 24.5 weight percent KOH solution. Compared to the conventional KOH etching systems, pyramidal hillocks, and wave-shaped structures on the etched surfaces were greatly reduced by using this system. After etching for time of 438 minutes, the average etched depth and the etch-rate were measured to be 537μm and 1.22μm/min, respectively. The average etching uniformity of etching depth was 0.87% in 5-inch wafer. Our results showed that the wafer rolling method enhanced etch uniformity and etch rate.
Wernicke’s Encephalopathy after Sleeve Gastrectomy for Morbid Obesity - A Case Report -
Hyo Jun Jeong,박지웅,김용진,Yang Gyun Lee,Yi Wook Jang,Jun Won Seo 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.4
Morbid obesity is a curable systemic disease that can cause several complications, including hypertension, diabetes mellitus, and osteoarthritis. However, it is not easy to control solely by conservative management. Bariatric surgeries, such as sleeve gastrectomy and gastric banding, are recently developed treatments that are applied to patients with morbid obesity in Korea. However, gastric surgery can cause surgical or metabolic complications, such as thiamine deficiency, which can lead to Wernicke’s encephalopathy. This metabolic complication presents with typical symptoms of confusion, ophthalmoplegia, nystagmus, and ataxia. In this case report, we present a case of Wernicke’s encephalopathy, which developed slowly following sleeve gastrectomy in a patient with morbid obesity.
( Hyo Jun Ahn ),( Myeong Jun Song ),( Jeong Won Jang ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: We aimed to evaluate the efficacy and safety of Tenofovir disoproxil fumarate (TDF) based therapy in naive and treatment experienced chronic hepatitis B (CHB) patients for 96 weeks in Korean real life practice. Methods: 209 CHB patients who had prescription for TDF at Seoul and Daejeon St. Mary’s hospital were enrolled from December, 2012 to October, 2014. We compared the virological responses and renal safety of naive and treatment experienced patients Results: Overall complete virological response (CVR) showed 80.4% and 84.6% of patients at week 48 and 96, respectively. In subgroup analysis, CVR at week 96 were 88.4%, 75.0 %, 75.5%, and 83.3%, in the lamivudine-resistant (LAM-R) group, Adefovir-resistant (ADV-R) group, multidrug-resistant (MDR) group, and suboptimal response group, respectively. In a multivariate analysis, ADV-R, MDR, HBV DNA, and HBeAg were independent predictors for CVR. In renal safety, Diabetes mellitus (DM), cirrhosis, and initial low estimated glomerular filtration rate were independent factors affecting Cr elevation (≥ 0.5mg/dL). Moreover, we note that 2 patients with DM and cirrhosis have experienced TDF-related Fanconi syndrome. Conclusions: TDF-based therapy demonstrated sustained viral suppression and a favorable safety throughout 2 years. Compared to the naive group, the LAM-R and suboptimal response group showed comparable efficacy, while the ADV-R group and MDR group both showed a relatively low efficacy. Also, the ADV-R group and MDR group were significantly associated with a low CVR. Close monitoring of renal function may be recommended in CHB patients receiving TDF, especially with DM and cirrhosis
기존 철도자갈도상의 콘크리트화에 대한 현장 적용성 평가 연구
장효준 ( Jang Hyo Jun ),심낙훈 ( Shim Nak Hoon ),이일화 ( Lee Il Hwa ),박영석 ( Park Young Suk ) 한국구조물진단유지관리공학회 2004 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.8 No.1
The objective of this study is to confirm the field application of coarse aggregates technology mixtured with high strength mortar under the rail. In the present study, the field tests are performed to find the field state and aggregate gradations and the laboratory tests are performed to find the compressive strength of the prepacked concrete cylinder specimens and the core specimens obtained at the field.
[제5분과/내구성/진단 및 보수·보강] 기존 철도자갈도상의 콘크리트화에 대한 현장 적용성 평가 연구
장효준(Jang Hyo Jun),심낙훈(Shim Nak Hoon),이일화(Lee Il Hwa),박영석(Park Young Suk) 한국구조물진단유지관리학회 2004 한국구조물진단학회 학술발표회논문집 Vol.- No.-
The objective of this study is to confirm the field application of coarse aggregates technology mixtured with high strength mortar under the rail. In the present study, the field tests are performed to find the field state and aggregate gradations and the laboratory tests are performed to find the compressive strength of the prepacked concrete cylinder specimens and the core specimens obtained at the field