http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Woonsung Na ),( Minjoo Yeom ),( Sun-woo Yoon ),( Aram Kang ),( Huijun Yuk ),( Daesub Song ) 대한인수공통전염병학회 2016 창립총회 및 학술대회 초록집 Vol.2016 No.1
Seasonal and pandemic influenza viruses have threatened global health and caused tremendous economic damage. Inactivated influenza virus vaccines (IIV) only elicit a homologous hemagglutinin, which protect narrow spectrum of influenza virus strains. To overcome the limitation, broadly protecting influenza vaccines are needed utilizing a conserved region of antigen, and epitopes that can evoke immune responses with CD8 T lymphocytes(CTL).The live attenuated influenza virus vaccine (LAIV) with intranasal administration can elicit specific CTL and mucosal serum antibody which cross-protects a wide range of influenza viruses. Here we utilized the H3N8 equine influenza virus that has partially deleted NS gene, which infect into host only one round without pathogenicity. This live EIV vaccine inoculated nasally elicits more effective protection than inactivated EIV vaccine with intramuscular injection, making promising candidate as EIV live attenuated vaccine.