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Inducible Nitric Oxide Synthase Inhibitor form Mela azedarach var. Japonica
Kwon, Hak-Cheol,Lee, Byeong-Gon,Kim, Seung-Hee,Jung, Chil-Mann,Hong, Sung-Youl,Han, Jeung-Whan,Lee, Hyang-Woo,Zee, Ok-Pyo,Lee, Kang-Ro The Pharmaceutical Society of Korea 1999 Archives of Pharmacal Research Vol.22 No.4
In bioassay-guided search for inducible nitric oxide synthase (iNOS) inhibitory compounds from higher plants of South Korea, two $\beta$-carboline (2) have been isolated form the cortex of Melia azedarach var. japonica. The structures of these compounds were elucidated on the basis of spectroscopic data. Compounds 1 to 2 showed marked inhibitory activity of iNOS on LPS-and interferon-${\gamma}$-stimulated RAW 264.7 cells.
Cytotoxic Constituents of Pilea mongolica
Kwon, Hak-Cheol,Lee, Kang-Ro,Zee, Ok-Pyo The Pharmaceutical Society of Korea 1997 Archives of Pharmacal Research Vol.20 No.2
Bioassay-guided fractionation of the aerial parts of Pilea mongolica(Urticaceae) afforded two cytotoxic triterpenoids, epi-oleanolic acid (I) and oxo-oleanolic acid (II). The structures of the compounds were confirmed by spectral and synthetic evidences. Compound I and compound II exhibited cytotoxicity against cultured human tumor cell lines, A549 (non small cell lung adenocarcinoma), SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), XF498 (CNS) and HCT15 (colon) with $ED_{50}$ values of $3.2-8.1{\mu}g/ml$ and $0.7-6.8 {\mu}g/ml$, respectively.
Cytotoxic Ergosterols from Paecilomyces sp. J300
Kwon, Hak-Cheol,Zee, Sang-Deuk,Cho, Sae-Yun,Choi, Sang-Un,Lee, Kang-Ro The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.6
Seven ergosterol derivatives (1-7) were isolated from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic means, their structures have been elucidated as 3$\beta$,5$\alpha$-dihydroxy-ergosta-7,22-diene (1), 5$\alpha$,6$\alpha$-epoxy-(22E,24R)-ergosta-8(14), 22-diene-3$\beta$,7$\alpha$-diol (2), 5$\alpha$,6$\alpha$-epoxy-(22E,24R)-ergosta-8, 22-diene-3$\beta$,7$\alpha$-diol (3), ergosta-4, 6, 8(14), 22-tetraene-3-one (4), ergosterol (5), ergosterol endoperoxide (6), 3$\beta$,5$\alpha$-dihydroxy-6$\beta$-methoxyergosta-7,22-diene (7). Compounds 3~7 showed moderate cytotoxicity against five tumor cells.
Cerebrosides and Terpene Glycosides from the Root of Aster scaber
Kwon, Hak-Cheol,Cho, Ock-Ryun,Lee, Kang-Choon,Lee, Kang-Ro The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.2
Three cerebrosides 2, 3, and 5 and two terpene glycosides 1 and 4 have been isolated from the methanol extract of the root of Aster scaber. Their structures were determined as 3-Ο-$\beta$-D-glucuronopyranosyl-oleanolic acid methyl ester (1), (2S, 3S, 4R, 2 R, 8Z, 15 Z)-N-2 -hydroxy-15 -tetracosenoyl-1-Ο-$\beta$-D-glucopyranosyl-4-hydroxy-8-sphingenine (2), (2S, 3S, 4R, 8Z)-N-octadecanoyl-1-Ο-$\beta$-D-glucopyranosyl-4-hydroxy-8-sphingenine (3), 1$\alpha$-hydroxy-6$\beta$-Ο-$\beta$-D-glucosyl-eudesm-3-ene (4), and (2S, 3S, 4R, 2 R, 8Z)-N-2 -hydroxy-hexadecanoyl-1-Ο-$\beta$-D-glucopyranosyl-4-hydroxy-8-sphingenine (5) on the basis of spectroscopic methods.
A New Acylglycosyl Sterol from Quisqualis Fructus
Kwon, Hak-Cheol,Min, Young-Duk,Kim, Kyung-Ran,Bang, Eun-Jung,Lee, Chong-Soon,Lee, Kang-Ro The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.4
A new acylglycosyl Sterol (4) was isolated from the MeOH extract of Quisqualis Fructus together with four known compounds. On the basis of spectroscopic data, their structures were elucidated as clerosterol (1), betulinic acid (2), methylursolate (3), 3-Ο-[6 -Ο-(8Z-octadecenoyl)-$\beta$-D-glucopyranosyl]-clerosterol (4) and $\alpha$-xylofuranosyluracil (5).
A New Indolinepeptide from Paecilomyces sp. J300
Kwon, Hak-Cheol,Kim, Kyung-Ran,Zee, Sang-Deuk,Cho, Sae-Yun,Lee, Kang-Ro The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.6
A new indolinepeptide (3) was isolated, together with two known compounds, a cerebroside (1) and an alloxazine (2), from silkworm larvae infected with Paecilomyces sp. J300. On the basis of spectroscopic data, their structures were elucidated as (4E, 8E, 25, 2'R, 3R )-N-2'-hydroxy-hexadecanoyl-1-O-$\beta$-D-glucopyranosyl-9-methyl-4, 8-sphingadienine (1), 7,8-dimethylalloxazine (2) and 3$\beta$,5-dihydroxy-1-N-methyl-indoline-2$\beta$-carbonyl amino-D-alanyl-erythro-$\beta$-hydoxyiso-leucinyl-glycine (3).
Phytochemical Constituents of Artemisia stolonofera
Kwon, Hak-Cheol,Choi, Sang-Un,Lee, Kang-Ro The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.4
Repeated column chromatographic separation of the $CH_{2}Cl_{2}$ extract of Artemisia stolonofera (Asteraceae) led to the isolation of a triterpene (I), a sesquiterpene (II), two aromatic compounds (III and IV) and a benzoquinone (V). Their structures were determined by spectroscopic means to be simiarenol (I), (1S,7S)-1 $\beta$-hydroxygermacra-4(15),5, 10(14)-triene (II), 3'-methoxy-4'-hydroxy-trans-cinnamaldehyde (III), vanillin(IV) and 2,6-dimethoxy-1,4-benzoquinone (V), respectively. Among these products, compound V showed significant cytotoxicity against five human tumor cell lines in vitro, A549 (non small cell lung adenocarcinoma), SK-OV-3 (ovarian), SK-MEL-2 (skin melanoma), XF498 (CNS) and HCT15 (colon) with ED_{50}$ values ranging from 1.33~4.22${\mu}g/ml$.
Phytochemical Constitutes of Artemisia japonica ssp. littoricola
Kwon, Hak-Cheol,Lee, Kang-Ro The Pharmaceutical Society of Korea 2001 Archives of Pharmacal Research Vol.24 No.3
The phytochemical study of the aerial parts of Artemisia japonica ssp. littoricola (Asteraceae) led to the isolation of two acetylenic compounds, (3R)-dehydrofalcarinol (2) and (3R)-dehydrofalcarindiol (6), two sesquiterpenes, $1{\beta}$, $6{\alpha}$-dihydroxy-4(15)-eudesmene (5) and oplodiol (8), and four phenolic compounds, eugenol (1), vanillin (3), 3'-methoxy-4'- hydroxy-trrans-cinnamaldehyde (4) and p-hydroxyacetophenone (7). Their structures were determined by chemical and spectroscopic methods.