Elderly kidney transplant recipients have favorable outcomes but increased infection-related mortality

임정훈,Lee Ga Young,Jeon Yena,Jung Hee-Yeon,Choi Ji Young,CHO, JANG-HEE,Park Sun Hee,김용림,Kim Hyung-Kee,Huh Seung,유은상,Won Dong Il,Kim Chan-Duck 대한신장학회 2022 Kidney Research and Clinical Practice Vol.41 No.3

Background: The number of elderly patients with end-stage kidney disease has been increasing, but the outcomes of kidney transplants (KT) remain poorly understood in elderly patients. Therefore, we evaluated the clinical outcomes of elderly KT recipients and analyzed the impact of elderly donors. Methods: This retrospective cohort study included patients who underwent KT between 2000 and 2019. KT recipients were divided into four groups according to a combination of recipient and donor age (≥60 or <60 years); elderly recipients: old-to-old (n = 46) and young-to-old (n = 83); young recipients: old-to-young (n = 98) and young-to-young (n = 796). We compared the risks of mortality, graft failure, and acute rejection between groups using Cox regression analysis. Results: The incidence of delayed graft function, graft failure, and acute rejection was not different among groups. Annual mean tacrolimus trough level was not lower in elderly recipients than young recipients during 10-year follow-up. Mortality was significantly higher in elderly recipients (p = 0.001), particularly infection-related mortality (p < 0.001). In multivariable Cox regression analysis, old-toold and young-to-old groups had increased risk of mortality (adjusted hazard ratio [aHR], 2.89; 95% confidence interval [CI], 1.14– 7.32; p = 0.03; aHR, 3.06; 95% CI, 1.51–6.20; p = 0.002). However, graft failure and acute rejection risks were not increased in elderly recipients. Conclusion: In elderly recipients, graft survival and acute rejection-free survival were not inferior to those of young recipients. However, mortality, especially risk of infection-related death, was increased in elderly recipients. Thus, low immunosuppression intensity might help decrease mortality in elderly recipients.

다발성 말초신경병증의 조기진단 : 적외선 체열촬영검사와 전류지각역치검사의 조합진단 Combination Diagnosis Using by Digital Infrared Thermogram and Current Perception Threshold

이삼규,김재형,최인성,이소영,한재영,조성렬,김재휴,노성만,정민영,정동진,김현성 全南大醫大 2001 전남의대학술지 Vol.37 No.3

한국에서의 간질의 사회적 낙인

이상암,유희정,허경,박형국,신동진,송홍기,정원영,권오영,이성수,김요식,김성은,이병인 대한간질학회 2002 대한간질학회지 Vol.6 No.2

가토 외고정 모델을 이용한 치밀체형 세라믹스의 골결합능 평가

이재협,이동호,이재학,공현식,안영준,류현승,서준혁,홍국선,김환,장봉순,이춘기 대한정형외과연구학회 2003 대한정형외과연구학회지 Vol.6 No.2

동씨침을 시술한 안면경련의 치험 3례

김태우,김효은,조명제,강영화,이재동,Kim, Tae-woo,Kim, Hyo-eun,Cho, Myung-je,Kang, Young-hwa,Lee, Jae-dong 대한침구의학회 2003 대한침구의학회지 Vol.20 No.1

Objective : Hemifacial spasm is painless uncommon disorder characterized by involuntary paroxysmal movement of one side of face, In this study, the effect of Dong-Si acupuncture therapy for three patients with hemifacial spasm were evaluated. Methods : We have treated them with acupuncture treatment of Dong-Si acupuncture points(Cheuk-Samni and Cheuk-ha-Samni) and evaluated the effect by Scott's scale, For the first two weeks, it was dine once a day, and after two weeks, the other day. Results : Before therapy, the grades of spasm intensity classified by Scott's description in three cases were 3. And after Dong-Si acupuncture therapy, the grade of one case was 0, and two cases were 1. Conclusion : The Dong-Si acupuncture therapy for hemifacial spasm was effective and will be attempted to the patients with it.

전자부품 제조업 근로자들의 시력변화에 대한 연구

이용만,안규동,이성수,함정오,김화성,리갑수,이병국 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.2

근접작업이 시력약화의 원인이 될 수 있는가를 알아보기 위하여 전자부품을 제조하는 2개 사업장에서 1991년에서 1993년까지 입사한 근로자들 중에서 근접작업으로 인정되는 마이크로칩을 조립하는 근접작업자 306명을 조사군으로, 대조군은 세탁기 타이머 및 일반 기계기구를 조립하는 작업자 154명, 계 460명을 선정하였다. 이들 대상자는 1991년 입사자는 1993, 1994, 1995년 시력을 조사하였으며, 1992년 입사자는 1993, 1994, 1995년 3년동안 조사를 하였으며, 1993년 입사자는 1994, 1995년 2년간 시력을 조사하였다. 대상자 중에서 입사시 안경을 착용한 근로자는 82명(17.8%)이었다. 따라서 남자 근로자와 안경착용자를 제외한 여성 근로자들 335명만을 추적 조사하여 다음과 같은 결론을 얻었다. 조사군에서 입사시 시력 1.0 이상이었던 근로자의 분포는 취업 1년 후 약 25-35% 정도 감소하였으며, 2년후에는 약 40-60% 정도의 감소를 나타내었고, 3년 후 약 50-65% 정도로 감소하였고 4년후에는 약 65% 이상 감소하였다. 그러나 대조군에서는 1.0 이상의 시력을 보였던 근로자들의 비율이 취업 1년 또는 2년 후 15-30%의 감소를 보이고 있으나 그 이후에는 큰 변동이 없었다. 이들의 시력변화를 근무년수에 따라 알아보기 위하여 조사된 시력을 순위변수로 하여 Kruskall-Wallis 검정을 시행한 결과 조사군, 대조군 모두에서 근속년수에 따른 순위의 합의 평균이 년차적으로 유의하게 감소하였으나, 입사시부터 근속년수에 따른 조사군과 대조군과의 순위합의 평균에 의한 시력차 비교에서 입사시 조사군의 순위합의 평균이 유의하게 높았던 것이 근무기간에 따라 대조군의 평균이 높아지면서 통계적 유의성이 없고 대체적으로 1년 이후부터 변화가 적은 것으로 나타나 근접작업으로 인한 시력약화를 추정할 수 있었다. This study was carried out to investigate that the close distance works were associated with decreased visual acuity. 306 workers were subjects who had been recruited from 1991 to 1993 in two electronic parts manufacturing factories, and 154 workers were controls who had been employed from 1991 to 1993 in launder machine timer and general machine assembly factories. Subjects who had been employed in 1991 and 1992 were follow up from 1993 to 1995, and subjects who had been employed in 1993 were from 1994 to 1995. The male workers as well as glasses wearing workers were excluded. Only 335 female workers were followed up to study the change of visual acuity. The results were as follows; The rate of workers with visual acuity over 1.0 at recruit year in subjects group was decreased about 25-35% after 1 year, 40-60% after 2 years, 50-65% after 3 years, and 65% after 4 years. While, the rate of workers with visual acuity over 1.0 at recruit year in control group was decreased about 15-30% after 1 or 2 years, and there was no more additional visual acuity reduction after then. Kruskall-Wallis test was performed to investigate the change of visual acuity in subject and control group by work duration. The means scores of ranks in both group were significantly decreased by work duration. The mean scores of ranks in subject group at recruit year were significantly higher than those in control group at recruit year, but these differences were disappeared after 1 year work. Therefore, this suggest that close distance workers may be affected their visual acuity.

Trichophyton verrucosum infection in Korea: Analysis on 224 patients from 1976 to 2015

( Dong Hyuk Eun ),( Jun Hong Park ),( Sun Young Moon ),( Yong Hyun Jang ),( Seok-jong Lee ),( Do Won Kim ),( Yong Jun Bang ),( Jae Bok Jun ),( Weon Ju Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Trichophyton (T.) verrucosum is a dermatophyte causing ringworm in cattle, distributed worldwide. It can be responsible for various inflammatory lesions of skin and scalp. In Korea, kerion celsi caused by T. verrucosum was first reported at 1986 in the southeast province of Korea. Since then, many patients infected with T. verrucosum have been reported in Young-nam province. There are few long-term studies about epidemiological characteristics of T. verrucosum. Objectives: To investigate the clinical and epidemiological characteristics of T. verrucosum infections in Korea. Methods: A total of 224 patients were diagnosed as T. verrucosum infection by fungal culture from 1976 to 2015. The data were based on a retrospective survey of medical records. Results: The annual incidence of patients with T. verrucosum infection had been increasing since the report in 1986. The number of patients showed a peak in 1988. After 2000, the number of patients had been decreasing. Female to male ratio showed a 1.2-fold predominance of female infection. And more than 15-year-old group was 59.4% of total patients. T. verrucosum infection was most commonly seen in spring and was found predominantly in patients living in rural areas. Face was most frequently involved, followed by arms. Conclusion: These findings provide useful information for understanding of T. verrucosum infection and future dermatophytosis prospects.

기종성 신우신염 1례

이재욱,구정태,서정일,양창헌,이정호,이동철,이영현,이활,이경섭 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

기종성 신우신염은 주로 당뇨병환자나 폐쇄성 요로질환을 가진 환자에 발생하며 특징적으로 신실질 및 그 주위조직에 가스를 형성하면서 심한 조직괴사를 일으키는 매우 드문 급성 화농성 신감염으로 사망률이 높은 질환이다. 이 질환은 1989년 Kelly와 MacCallum에 의해 처음 보고된 이래 외국문헌에 약 90례 정도가 보고되어 있으며 국내에는 28례가 보고되어 있다. 수액 및 전해질 보충, 인슐린 투여를 통한 적절한 혈당조절 및 항생제 투여등의 내과적 치료와 절개배농 및 신적출술등의 수술적 치료 방법이 있다. 내과적 치료로 가스의 감소가 없는 경우에는 즉각적인 수술적 치료를 시행하여야하므로 이 가스변화에 대한 추적관찰이 중요하다 하겠다. 본 저자들은 당뇨병환자에서 발생한 기종성 신우신염 1례를 내과적 요법을 치험하였기에 문헌고찰과 함께 보고하고자 한다. Emphysematous pyelonephritis is rare, life-threatening infection of the renal parenchyma and perirenal tisseue. This disease is characterized by the production of intrarenal and perirenal gas and is frequently encountered in patients with diabetes mellitus or urinary obstruction. We experienced a case of emphysematouse pyelonephritis in a 62 years old women with poorly controlled diabetes mellitus who had been managed with medical theraphy. So we report this case with a review of the referenced literatures.

Correlations between skin prick test and specific IgE measured by CAP system of inhalant allergens

( Young Hee Nam ),( Soo Keol Lee ),( Dong Sub Jeon ),( Hye Won Lee ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Background/Aims: It appears that much of the discordance between skin prick test (SPT) and ImmunoCAP in clinical practice. We investigated the correlation between SPT and ImmunoCAP for inhalant allergens. Methods: A total of 523 patients who were tested SPT and ImmunoCAP were from July 2012 to June 2013 in Dong-A university hospital, and the results of two tests were compared. For SPT, wheal 3x3 mm or greater at 15min, and the result of ImmunoCAP of >0.35 kU/L was considered positive, respectively. Results: Of the study subjects, bronchial asthma was 22.2% (n=116), rhinitis 28.9% (n=151), allergic conjuctivitis 12.2% (n=64), and atopic dermatitis 0.8% (n=4). SPT were positive in 52% (n=272) of the subjects. The positive responses and agreements of SPT with ImmunoCAP for each allergens were Dermatophagoides pteronyssinus (32.1% for SPT and 36.1% for ImmunoCAP; aggrement 79.2%), Dermatophagoides farina (13.6% and 47.8%; 75.2%), birch (12.8% and 47.6%; 42.9%), beech (10.3% and 44.6%; 44.6%), ragweed (3.6% and 25%; 84.6%) and mugwort (9.4% and 43.8%; 82.9%). Conclusions: The aggrement between SPT and ImmunoCAP was various according to allergens. We should determine the clinical relevance of the allergen sensitization using both SPT and ImmunoCAP not alone with combination of clinical symptoms.

심산 차영배의 삼위일체론에 대한 연구

이동영 ( Dong Young Lee ) 한국복음주의조직신학회 2021 조직신학연구 Vol.38 No.-

본 논문의 목적은 한국 교회 안에서 삼위일체론에 대한 올바른 이해와 전수를 위하여 평생을 노력했던 개혁주의 조직신학자 심산 차영배의 삼위일체론을 분석하고 평가해 보는데 있다. 차영배는 삼위일체론을 기독교 신론의 일부가 아니라 신론 그 자체이며, 단지 신론이 아니라 ‘신학의 본질적 원리’(principium essendi )라고 천명했다. 차영배는 자신의 저서 『개혁교의학. 삼위일체론』에서 교리사적이고 신조학적인 연구를 통하여 삼위일체교리에 대한 자신의 견해를 개진하였다. 특히 『웨스트민스터 신앙고백서』 2장 3절에 대한 자신의 해석에서 우리는 삼위일체론에 대한 차영배의 이해의 정수와 만나게 된다. 차영배에 따르면 『웨스트민스터 신앙고백서』(1648)의 삼위일체론이 삼위를 먼저 구분하고 삼위가 소유한 동일한 본질을 일체로 파악하고 있다고 해석한다. 그렇게 함으로써 그는 장로교회의 표준문서 가운데 하나인 『웨스트민스터 신앙고백서』의 삼위일체론이 「니케아-콘스탄티노플신경」(381)을 통하여 동방교회와 서방교회가 공동으로 고백하는 공교회의 삼위일체론에 정확하게 부합됨을 논증함으로써, 『웨스트민스터 신앙고백서』의 삼위일체론의 공교회적인 성격을 잘 규명해 주었다는 것은 실로 그의 신학적 기여가 아닐 수 없다. 그러나 그에게도 아쉬운 점은 있다. 차영배가 삼위일체론을 기독교 신론의 일부가 아니라 신론 그 자체이며, 단지 신론이 아니라 신학의 본질적 원리라고 천명했음에도 불구하고 그가 삼위일체론을 신학의 원리로 삼아 교의 각론을 해명하고 해설하는 조직신학을 저술하지 못했다는 것, 그리고 그가 삼위일체론의 올바른 해석과 이해에만 집중한 나머지 우리의 신앙 및 삶과 관련하여 이 교리가 함의하고 있는 실천적인 의미를 규명해 주지 못했다는 것은 실로 아쉬운 일이 아닐 수 없다. 그러므로 이러한 조직신학 책의 저술은 차영배의 어깨 위에서서 계속해서 발전해 나가야만 하는 후학들의 몫으로 남아 있다. The purpose of this paper is to analyze and evaluate a Reformed Systematic Theologian Young-Bae Cha’s understanding of the Trinity, which has worked for its correct understanding and transfer within the Korean Church. He declares that the doctrine of Trinity is not part of the Christian doctrine of God, but the doctrine itself, and that this doctrine is not just the doctrine of God but the essential principle (principium essendi) of theology. In his book, “Reformed Dogmatics: doctrine of the Trinity ,” he developed his own view of doctrine of the Trinity through doctrine-historical and creed-historical studies. In particular, in his own interpretation of “the Westminster Confession of Faith 2, 3,” we encounter the essence of his deep understanding of the Trinity. According to him, the doctrine of Trinity in “The Westminster Confession of Faith”(1648) distinguishes tree Persons first and then regards the same essence(ομοουσιος. consubstantia) possessed by three persons, namely the Father, the Son and the Holy Spirit as unity (unitas). By doing so, he demonstrates that the Trinity of “The Westminster Confession of Faith,” one of the standard documents of the Presbyterian Church, is in accord with the doctrine of Trinity of the catholic church jointly confessed by the Eastern and Western Churches through “The Nicaeno-Constantinopolitanum”(381). It is indeed his theological contribution that he well identified the ecumenical character of the Trinity of “The Westminster Confession of Faith.” However, there is the following disappointment to him. 1) First, he failed to write a systematic theology that uses the doctrine of Trinity as a principle of theology to explain and explain another doctrines. 2) Second, he failed to elucidate the practical implications of this doctrine in relation to our faith and life, because he focuses only on its correct interpretation and understanding. Therefore his successors must continue to develop on his shoulders, that they may overcome speculation of the doctrine of Trinity.