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Characterization of Mice Deficient of Leukaemia Inhibitory Factor
Cheil Moon 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Leukemia inhibitory factor (LIF) is a multifunctional neuropoietic cytokine involved in neuronal development. Mice with target disruption of the LIF gene are available due to transgenic technology and biotechnology. However, LIF-deficient mice have been reported to be embarrassingly poor in replacement and display awkward colony phenotypes. From total 265 breeds, significantly smaller breeding rate and litter numbers were observed from homozygous male pairs. And LIF-deficient mouse colony did not follow rules of genetics. Both heterozygote male and homozygote male colonies showed significantly higher male birth rate than the hypothetical value. Taken together, epochal improvement in acquiring transgenic animals may be necessary to facilitate large-scale or long-term studies using the LIF-deficient mice. Therefore, better strategies to assure enough numbers of LIF-deficient mice are imminent. In order to achieve this goal, long-term monitoring of the colony has been performed and possible solutions also have been suggested.
Moon, Cheil,Liu, Bridget Q.,Kim, So Yeun,Kim, Esther J.,Park, Yun Ju,Yoo, Joo-Yeon,Han, Hyung Soo,Bae, Yong Chul,Ronnett, Gabriele V. Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of neuroscience research Vol.87 No.5
<P>Leukemia inhibitory factor (LIF), a neuropoietic cytokine, has been implicated in the control of neuronal development. We previously reported that LIF plays a critical role in regulating the terminal differentiation of olfactory sensory neurons (OSNs). Here, we demonstrate that LIF plays a complementary role in supporting the survival of immature OSNs. Mature OSNs express LIF, which may be elaborated in a paracrine manner to influence adjacent neurons. LIF null mice display more apoptotic immature neurons than do their wild-type littermates. LIF treatment of dissociated OSNs in vitro significantly reduces the apoptosis of immature OSNs. Double immunocytochemical analysis indicates that the survival of immature OSNs is dependent on the presence of LIF. LIF activates the phosphoinositide 3-kinase (PI3K) pathways and induces the expression of the antiapoptotic molecule Bcl-2 in OSNs, whereas inhibition of the PI3K pathway blocks LIF-dependent OSN survival and Bcl-2 induction. Thus, LIF plays a central role in maintaining the size and integrity of the population of immature neurons within the olfactory epithelium; this population is critical to the rapid recovery of olfactory function after injury. LIF may play a similar role elsewhere in the CNS and thus be important for manipulation of stem cell populations for therapeutic interventions. © 2008 Wiley-Liss, Inc.</P>
( Seungyeong Im ),( Cheil Moon ) 생화학분자생물학회 2015 BMB Reports Vol.48 No.11
Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases. [BMB Reports 2015; 48(11): 599-608]
Distinct Developmental Features of Olfactory Bulb Interneurons
Kim, Jae Yeon,Choe, Jiyun,Moon, Cheil Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.3
The olfactory bulb (OB) has an extremely higher proportion of interneurons innervating excitatory neurons than other brain regions, which is evolutionally conserved across species. Despite the abundance of OB interneurons, little is known about the diversification and physiological functions of OB interneurons compared to cortical interneurons. In this review, an overview of the general developmental process of interneurons from the angles of the spatial and temporal specifications was presented. Then, the distinct features shown exclusively in OB interneurons development and molecular machinery recently identified were discussed. Finally, we proposed an evolutionary meaning for the diversity of OB interneurons.
Morphological evidences in circumvallate papilla and von Ebners' gland development in mice
Wern-Joo Sohn,Gi-Jeong Gwon,Chang-Hyeon An,Cheil Moon,Yong-Chul Bae,Hitoshi Yamamoto,Sanggyu Lee,Jae-Young Kim 대한해부학회 2011 Anatomy & Cell Biology Vol.44 No.4
In rodents the circumvallate papilla (CVP) with its underlying minor salivary gland the von Ebners' gland (VEG) is located on the dorsal surface of the posterior tongue. Detailed morphological processes to form the proper structure of CVP and VEG have not been properly elucidated. In particular the specific localization patterns of taste buds in CVP and the branching formation of VEG have not yet been elucidated. To understand the developmental mechanisms underlying CVP and VEG formation detailed histological observations of CVP and VEG were examined using a three-dimensional computeraided reconstruction method with serial histological sections and pan-Cytokeratins immunostainings. In addition to defi ne the developmental processes in CVP and VEG formation we examined nerve innervations and cell proliferation using microinjections of AM1-43 and immunostainings with various markers including phosphoinositide 3-kinase Ki-67 PGP9.5 and Ulex europaeus agglutinin 1 (UEA1). Results revealed specific morphogenesis of CVP and VEG with nerve innervations patterns evaluated by the coincided localization patterns of AM1-43 and UEA1. Based on these morphological and immunohistochemical results we suggest that nerve innervations and cell proliferations play important roles in the positioning of taste buds in CVP and branching morphogenesis of VEG in tongue development.
Park, Sook Kyung,Kim, Jong Ho,Yang, Eun Sun,Ahn, Dong Kuk,Moon, Cheil,Bae, Yong Chul Springer Science + Business Media 2014 BRAIN STRUCTURE AND FUNCTION Vol.219 No.5
<P>Neurons in the main olfactory bulb relay peripheral odorant signals to the anterior piriform cortex (aPir), whereas neurons of the accessory olfactory bulb relay pheromone signals to the medial amygdala (MeA), suggesting that they belong to two functionally distinct systems. To help understand how odorant and pheromone signals are further processed in the brain, we investigated the synaptic connectivity of identified axon terminals of these neurons in layer Ia of the aPir and posterodorsal part of the MeA, using anterograde tracing with horseradish peroxidase, quantitative ultrastructural analysis of serial thin sections, and immunogold staining. All identified boutons contained round vesicles and some also contained many large dense core vesicles. The number of postsynaptic dendrites per labeled bouton was significantly higher in the aPir than in the MeA, suggesting higher synaptic divergence at a single bouton level. While a large fraction of identified boutons (29%) in the aPir contacted 2-4 postsynaptic dendrites, only 7% of the identified boutons in the MeA contacted multiple postsynaptic dendrites. In addition, the majority of the identified boutons in the aPir (95%) contacted dendritic spines, whereas most identified boutons in the MeA (64%) contacted dendritic shafts. Identified boutons and many of the postsynaptic dendrites showed glutamate immunoreactivity. These findings suggest that odorant and pheromone signals are processed differently in the brain centers of the main and accessory olfactory systems.</P>