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- 저자 : ( Asmita Singh ) (검색결과 2 건)
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Anjna Sharma,Asmita Magotra,Santosh Kumar Rath,Priya Wazir,Utpal Nandi,Surrinder Koul,Payare Lal Sangwan,Ajai Prakash Gupta,Gurdarshan Singh 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.5
Plant derived natural products have been the major source for treatment of diseases traditionally but with the advent of modern systems of medicine, there is need to explore the active constituents present in it followed by modification for better therapeutic activity, low toxicity and favorable pharmacokinetics to become a drug molecule. A simple, rapid and sensitive high-performance liquid chromatography–tandem mass spectrometry (LC– MS/MS) method was developed and validated according to Food and Drug Administration guidelines for determination of IS01957, a derivative of naturally occurring para coumaric acid in mice plasma. The extraction of the analyte and the internal standard (Carbamazepine) from the plasma samples involved protein precipitation using acetonitrile. Results of validation parameters were met with the acceptance criteria of the FDA guidelines. Method was highly sensitive (5 ng/mL) that could determine very low concentration of compound in plasma The developed and validated method was successfully applied to determine compound’s metabolic stability in mouse liver microsomes (MLM) and human liver microsomes (HLM). Test compound was found to be stable in MLM and HLM in the experimental conditions. Metabolic stability data was extrapolated which was further correlated to pharmacokinetics study in mice through oral, intraperitoneal and intravenous administration. In-vitro half life was found to be greater than 2 h in both MLM and HLM. Hepatic extraction ratio of the compound was found to be in the intermediate range. Pharmacokinetic evaluations revealed that it is a suitable candidate for intraperitoneal as well as oral administration.
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( Ragita C. Pramudya ),( Asmita Singh ),( Han-seok Seo ) 한국감성과학회 2019 한국감성과학회 국제학술대회(ICES) Vol.2019 No.-
Recently, consumer awareness toward sustainable lifestyles has increased, and the use of reusable straws is becoming the norm. There is ample evidence through previous research that extrinsic factors can influence consumer acceptance, perception, and purchasing behavior of food products. However, there have been no previous studies pertaining the influences of straw materials on consumer experience of products. This study aimed to determine the effects of straw materials on evoked emotions and sensory perception of consumers toward cold tea beverages. Five materials of straws were used in this study, including plastic, silicone, stainless steel, copper, and paper. Fifty cold-tea consumers (23 females) aged between 18 and 59 years old rated the liking, sensory intensities, and emotional responses toward unsweetened cold black tea served with the aforementioned straws. Results showed that the plastic straws induced most bitter, sour, and astringent perceptions, while the opposite trends were observed with copper straws. Emotions evoked by cold tea beverages differed with the different materials of straws, indicating that straw materials may influence consumer experience of cold tea products. In conclusion, this study provides empirical evidence that sensory perception and emotions toward cold tea beverages can vary as a function of the material type of straws.
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