De pronominum primae personae in libris 書經 et 詩經 usu

Merz, Constantin Holzhausen 1882 국내석사

U@ber die Kinetik der Aminierung von 4-Chlorbutanol zu 4-Aminobutanol

Merz, Erich [s.n.] 1970 국내박사

Temporal logic as a programming language

Merz, Stephan 1992 국내박사

Environmental influence on strategy and performance in small Technology-based firms : a resource dependence perspective

Merz, George Russell UMI dissertation services 1987 국내박사

Domains and Anisotropy in SrTiO3

Merz, Tyler A ProQuest Dissertations & Theses Stanford Universit 2018 해외박사(DDOD)

SrTiO3 has been a material of great interest to the scientific community for decades, but despite the long standing interest in it, there have been a number of aspects around its low temperature properties which have been taken for granted. The received wisdom in the community has been largely that the tetragonal phase of SrTiO3 is irrelevant to the low temperature physics. The smallness of the tetragonality in SrTiO3 makes this quite a compelling argument at first glance, but closer examinations have shown that this smallness in structural tetragonality does not always lead to a smallness in other anisotropic quantities. Measurements of the anisotropic dielectric constant from the 1970s by Sakudo and Unoki showed anisotropies of approximately two at low temperatures. More recently, spatially resolved scanning quantum interference device measurements of electrical properties have shown anisotropies of tens of percent which are strongly suggestive of domains in SrTiO3 systems. These more recent measurements have made it clear that a careful reexamination of the assumption that the tetragonality of SrTiO3 is largely irrelevant is in order. This thesis attempts to make a careful examination of the question of the influence of SrTiO3's tetragonality on the electric properties of not only bulk SrTiO3, but also SrTiO3 heterostructures. While the study of the intrinsic properties of SrTiO3 is a niche topic, the results of this thesis extend beyond just the bulk SrTiO3 community. Since SrTiO3 is used widely as a substrate for oxide heterostructures, whose low temperature properties are then examined, the results of this thesis will be of interest to anyone working with systems involving SrTiO3 at low temperature, and in particular electrical properties. Specifically the fields of mono-layer iron selenide on SrTiO3 and cuprate superconductor thin films should consider carefully the effects of the tetragonality of SrTiO3 and potentially its domain structure. The methods which are used in this thesis for controlling the domain structure of SrTiO3 are applicable to other material systems which undergo structural phase transitions and may eventually form the basis for more low temperature experiments involving SrTiO3, where particular knowledge of the domain structure is vital.

Characterizing protein conformations using Copper-Based Pulsed Dipolar ESR Spectroscopy and complimentary biophysical methods

Merz, Gregory Edward Cornell University 2016 해외박사(DDOD)

Proteins play an important and diverse role in all living organisms. If proteins are unable to carry out their prescribed functions, the results can be problematic, or even fatal, for an organism. For example, in humans, Alzheimer's and Parkinson's are just 2 of the many diseases caused by proteins which either do not function, or function incorrectly. Proteins can also perform chemical transformations which are very difficult via synthetic methods, such as the oxidation of methane to methanol and the fixation of dinitrogen to ammonia. Understanding the mechanisms of these processes may lead to much more efficient catalysts, greatly reducing the large energy expenditures currently required. In biochemistry, the link between structure and function has been well established, and so in order to understand the mechanisms and functions of proteins, we must understand their structures. In many cases, the structures of flexible proteins can be difficult to elucidate, especially if multiple conformations exist simultaneously. Here, we use copper-based pulsed dipolar ESR spectroscopy (PDS) and other, complimentary biophysical and biochemical methods to characterize protein conformations in flexible proteins. These include mutants of Superoxide Dismutase 1 (SOD1) which cause familial ALS, and the Drosophila melanogaster circadian clock protein Period. By using these techniques, we show that fALS mutants of SOD1 tend to aggregate in solution as opposed to the wild-type (WT) protein which does not. Furthermore, we propose a structural mechanism by which this aggregation occurs. In the Period protein, we have discerned small differences in the conformation of mutants that mimic phosphorylation vs. the WT. These subtle changes may cause differences in circadian behavior observed in fruit flies.

Molecular Simulations Uncover the Nanomechanics of Heat Shock Protein (70 kDa) & Indentation Simulations of Microtubules Reveal Katanin Severing Insights

Merz, Dale R., Jr University of Cincinnati ProQuest Dissertations & 2020 해외박사(DDOD)

The nanomechanics of heat shock protein (70 kDa) and the mechanical properties of the microtubule lattice were investigated with coarse-grained molecular pulling and indentation simulations, respectively. Heat shock protein is a molecular chaperone known for its role in folding nascent peptides as they exit the ribosome and preventing protein aggregation. Preventing protein aggregation is critical for combating neuro-degenerative diseases like Alzheimer's and Parkinson’s disease. We uncovered mechanical rigidification in the substrate binding domain and lobe II of the nucleotide binding domain upon hydrolysis. We found that this rigidification was communicated allosterically and through noncontiguous residues of the protein’s subdomains contrary to the literature previously indicating the interdomain linker as the means of allosteric communication. Concerning my other areas of research, the investigations into microtubule severing by severing proteins like katanin, we discovered important mechanical properties pertinent for how microtubule severing occurs. Katanin is a severing protein expected to target microtubule lattice defects in order to induce severing. The seam was thought to be a lattice defect. Understanding how severing proteins interact with the microtubule lattice permits scientists to better understand and eventually manipulate or control cellular division. With this understanding, they can better develop and engineer pharmaceutical drugs capable of diverting, interrupting, or even accelerating the severing process. By comparing the force of indentation on and around the seam, we were able to eliminate from consideration the seam as a microtubule defect by comparing and identifying similar distributions of critical breaking forces on and off of the seam.

Precision Measurements of Higgs Boson Couplings in the Diphoton Decay Channel with Run-2 of the ATLAS Detector

Merz, Garrett ProQuest Dissertations & Theses University of Mich 2021 해외박사(DDOD)

Biopsychosocial pathways of pain in patients with systemic sclerosis

Merz, Erin Lynn University of California, San Diego 2014 해외박사(DDOD)

Systemic Sclerosis (SSc) is a rheumatic disease characterized by fibrosis of the skin and internal organs. Patients are at risk for poor quality of life, including significant pain. This dissertation evaluated a biopsychosocial model of pain-related quality of life in SSc. Data from the Genetics versus ENvironment In Scleroderma Outcome Study (GENISOS), a prospective cohort study of patients with SSc were used to test the study aims. Study 1 used baseline data to evaluate the factor structure of the Illness Behavior Questionnaire. Four previously derived solutions were tested but none were sufficiently valid or reliable. Exploratory analysis suggested that there were five factors that were relevant to SSc patients: Symptom Bother, Health Worry, Interpersonal Functioning, Other Life Worries, and Affective Inhibition. These indices were related to fatigue, pain, disability, social support, and mental health but not disease severity. Study 2 utilized baseline data to derive biopsychosocial profiles of SSc patients based on indicators of disease severity, perceived physical health, health worry, mental health, and social support. Three classes, which were distinguished by different trait patterns, were termed Managing, Resilient, and Distressed. Results suggested that the Distressed group, which represented individuals with less severe disease but poor psychosocial functioning had the highest pain and analgesic usage. Study 3 evaluated pain over time with regard to medical, psychological, and social characteristics. Pain generally improved for all patients. Individuals with diffuse disease reported worse initial pain, although both classifications had same rate of change. However, when psychosocial characteristics were added to the model, disease classification was no longer a significant predictor. Individuals with better mental health and perceived physical health reported better pain at disease onset. Change in pain over time was moderated by perceived physical health and social support. Overall, the findings suggest that, even in the context of a disease which is characterized by significant damage of bodily tissue, the overall experience of pain was best explained by psychological and social phenomena. Emotional and social functioning, which are potentially modifiable risk factors, may be important targets for comprehensive pain management in this population.

Does Participation in a Peer Mentoring Program Impact the Mentor’s Ethnic Identity Development? A Mixed-Method Study of Asian American Undergraduate Mentors

Lim, Merz Burghess Panares Roy ProQuest Dissertations & Theses New England Colleg 2023 해외박사(DDOD)

In this mixed-method study, participation in a peer mentoring program’s impact on ethnic identity development is explored, with particular emphasis on Asian American mentors. There has been a lack of research on the effects on the mentors who participated in peer mentoring programs. This study intended to provide an understanding of how the mentoring program contributes to their ethnic identity development. The quantitative phase consisted of a pre- and post-survey based on the Multigroup Ethnic Identity Measure (Phinney, 1992) to identify the respondents’ current stage of ethnic identity (N = 63). The survey was conducted between August 2021 and April 2022. Pre- and post-survey results revealed no statistically significant difference for the means of the students’ overall ethnic identity achievement; identity search subscale; or affirmation, belonging, and commitment subscales. The qualitative phase was exploratory, consisting of a phenomenological analysis of open survey responses and 13 in-depth interviews, which were conducted between January 2022 and March 2022. Purposeful selection was applied to select Asian American undergraduate students serving as peer mentors. The use of Colaizzi’s (1978) method of phenomenological analysis allowed for the moving of significant statements to four clustered themes that describe a peer mentor’s ethnic identity development through their participation in an ethnic-based mentoring program. Findings suggested participation in an ethnic-based peer mentoring program provides opportunities to explore and understand their ethnic identity. Recommendations are made which institutions can use to enhance peer mentors’ ethnic identity development.