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RISS 인기검색어
- 검색키워드
- 저자 : Dibbern, Margrit (검색결과 3 건)
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Core-shell microspheres for biomedical applications
Dibbern, Elizabeth Marie University of Illinois at Urbana-Champaign 2007 해외박사(DDOD)
Substantial improvements in current therapies and diagnostics will occur using new methods for the delivery of drugs and imaging agents. Core-shell protein or polymer microspheres are biocompatible vesicles that have been used to meet the goal of transporting drugs or contrast agents to diseased tissues via the circulatory system. They consist of a hydrophobic core surrounded by a protein or polymer shell. Typically, these spheres had been formed sonochemically from bovine serum albumin and were stabilized by inter-protein covalent crosslinking of cysteine residues. In this thesis, I have developed a nanoscale protein sphere through the addition of surfactants to the sonication solution. Spheres with diameters of 300 nm were created and have been shown to be robust. In addition to decreasing the size of the protein microspheres, this thesis contains the development of coreshell spheres made from other polymers. These spheres are held together through strong hydrogen bonds or ion bridges rather than covalent bonds, but are stable and would be useful for biomedical applications. The polymer spheres were also formed using methods other than sonication including sparging, extrusion and blending. A new imaging technique, magnetomotive optical coherence tomography (MMOCT), was developed in conjunction with the Boppart lab to image the microspheres in vivo. This system uses encapsulated magnetite in a modulated magnetic field to image diseased tissues. The microspheres were also targeted to tumor cells via an RGD motif (arg-gly-asp) which has been shown to target integrin receptors that are more prevalent on tumors than healthy tissue. In conclusion, I have developed a nanoscale, targeted sphere that can be imaged in vivo.
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Riots in the Streets: Journalism, Mob Violence, and the Hollywood Left, 1949 to 1951
Dibbern, Doug New York University 2010 해외박사(DDOD)
This dissertation examines a cycle of movies released between 1949 and 1951 that explores the relationship between journalism and mob violence. It is my contention that these films manifested the anxieties of Hollywood progressives who felt besieged by the conservative politics that they believed were coming to dominate Los Angeles, the film community, and the United States during the years in which hundreds of radicals suspected that they'd eventually be blacklisted or forced to name names. Unable to make movies about the issues most important to them - such as the persecution of communists and the labor struggle in the film industry - they latched on to acceptable topics like racism and the economic plight of the postwar working class. In crafting their films, progressives were influenced chiefly by a series of political events in Los Angeles in which rioting was a prominent factor, especially the Conference of Studio Unions strikes of 1945 and 1946. In each of these instances, the major Los Angeles daily newspapers covered the events with a reactionary agenda, and in each case, Hollywood progressives responded by publishing their own newspapers and pamphlets to tell their side of the story. The movies that liberals produced in those years were the logical cinematic parallel to progressives' political and journalistic advocacy; they recast political events from California's recent past as politically-engaged narratives that were inflected with their own fears of persecution. The dissertation's final chapters focus on three of the most significant films in the cycle. The Lawless (1950), written by Daniel Mainwaring and directed by Joseph Losey, re-worked the story of the Sleepy Lagoon Murder and Zoot Suit Riots of 1942 and 1943; The Sound of Fury (1950), written by Jo Pagano and directed by Cy Endfield, was inspired by a 1933 lynching of two white men in San Jose; and The Well (1951), written and directed by Leo Popkin, Russell Rouse, and Clarence Greene, fused the story of a race riot with a reformulation of a recent media phenomenon in Los Angeles, the rescue attempt of a girl named Kathy Fiscus who had fallen down a well.
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