Recent studies suggested that secreted frizzled-related protein 2 (SFRP2) augment Wnt-mediated β-catenin signaling and increase alkaline phosphatase (ALP) activity, an important indicator of DP activity. These findings prompted us to investigate the ...
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SFRP2가 모낭의 Wnt 신호 전달에 미치는 영향 = Effects of SFRP2 on the Wnt/β-catenin signaling of hair follicle
한글로보기https://www.riss.kr/link?id=T13255951
- 저자
-
발행사항
대구 : 경북대학교 대학원, 2013
- 학위논문사항
-
발행연도
2013
-
작성언어
한국어
- 주제어
-
DDC
616.54 판사항(22)
-
발행국(도시)
대구
-
형태사항
34, i p. : 삽화 ; 26 cm
-
일반주기명
지도교수: 김문규
참고문헌 수록 -
소장기관
- 경북대학교 중앙도서관
- 국립중앙도서관
- 경북대학교 중앙도서관
-
0
상세조회 -
0
다운로드
인용문이 복사되었습니다.
부가정보
다국어 초록 (Multilingual Abstract)
Recent studies suggested that secreted frizzled-related protein 2 (SFRP2) augment Wnt-mediated β-catenin signaling and increase alkaline phosphatase (ALP) activity, an important indicator of DP activity. These findings prompted us to investigate the role of SFRP2 in human hair follicle and hair cycling. Herein we report that SFRP2 augments Wnt3a-mediated elevation of transcriptional activity of β-catenin, increasement of expression of β-catenin target genes and accumulation of β-catenin in nucleus of DP cells. In addition, SFRP2 and SFRP2 messenger RNA expression are most upregulated in follicular keratinocytes of early anagen stage during hair cycle progression. Moreover, SFRP2 is upregulated in non-balding DP cell compared with balding DP cell unlike dickkopf 1 (DKK1). Taken together, our data strongly suggest that SFPR2 is involved in maintain of anagen stage during the hair cycle by regulating the activity of Wnt/ β-catenin.
Recent studies suggested that secreted frizzled-related protein 2 (SFRP2) augment Wnt-mediated β-catenin signaling and increase alkaline phosphatase (ALP) activity, an important indicator of DP activity. These findings prompted us to investigate the role of SFRP2 in human hair follicle and hair cycling. Herein we report that SFRP2 augments Wnt3a-mediated elevation of transcriptional activity of β-catenin, increasement of expression of β-catenin target genes and accumulation of β-catenin in nucleus of DP cells. In addition, SFRP2 and SFRP2 messenger RNA expression are most upregulated in follicular keratinocytes of early anagen stage during hair cycle progression. Moreover, SFRP2 is upregulated in non-balding DP cell compared with balding DP cell unlike dickkopf 1 (DKK1). Taken together, our data strongly suggest that SFPR2 is involved in maintain of anagen stage during the hair cycle by regulating the activity of Wnt/ β-catenin.
목차 (Table of Contents)
- 서론 1
- 재료 및 방법 4
- 결과 8
- 고찰 23
- 요약 27
- 서론 1
- 재료 및 방법 4
- 결과 8
- 고찰 23
- 요약 27
- 참고문헌 28
- 초록 i
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