난소를 적출한 Rats에서 우울증, 불안장애, 식이섭취에 대한 석류추출물의 효과 = The Effect of Pomegranate on Depression, Anxiety, and Food Intake in Ovariectomized Rats

다국어 초록 (Multilingual Abstract)

Objectives: To determine whether or not pomegranate extract can affect depression, anxiety, and food intake in ovariectomized rats. Methods: Seventy-nine female Sprague-Dawley rats were divided into six groups: A, no operation and no drug intake; B, sham operation and distilled water; C, ovariectomy and distilled water; D, ovariectomy and 10% dilute pomegranate extract; E, ovariectomy and 20% dilute pomegranate extract; and F, ovariectomy and 40% dilute pomegranate extract. Beginning 2 days after surgery, drugs were administrated for 4 weeks. After that, the rats were subjected to the elevated plus maze (EPM) test and forced swim test (FST). Results: The 10% pomegranate extract had a lower % closed arm entry frequency in the EPM test. A pomegranate dose-dependent decrease in the duration of immobility duration in FST was shown. Pomegranate did not reverse ovariectomy-related hyperphagia and weight gain. Conclusion: Pomegranate extract improved depression and anxiety in a postmenopausal model with ovariectomized rats. (J Korean Soc Menopause 2010;16:39-45)