주요우울증에서 우울과 불안 증상의 심각도에 따른 뇌파 A1,A2, Percent 비대칭 지표들의 특성 연구 = EEG A1, A2, and Percent Asymmetry Indices in Major Depressive Disorder ; The Importance of Symptom Severity of Depression and Anxiety

다국어 초록 (Multilingual Abstract)

Objectives : In this study we investigated characteristics of asymmetry pattern of EEG in patients with major depressive disor-der according to the severity of depression and anxiety symptoms, employing A1, A2, and Percent (PCT) asymmetry indices.
Methods : Subjects involved in this study were 11 healthy controls and 11 patients with major depressive disorder who have taken no medicines for four weeks just before the study. These subjects were selected so that the two groups can have no difference in gender and age. Beck Depression Inventory (BDI), 17-item Hamilton Depression Rating Scale (HDRS), Zung's Self-Rating Depression Scale (SDS) and Spielberger's State-Trait Anxiety Inventory (STAI) were used to evaluate depression and anxiety symptoms, respectively. Resting EEG was recorded &om F3, F4, C3, C4, T7, T8, 01 and 02 electrode sites.
Results : The temporal region showed a difference in A1, A2, and PCT asymmetry indices between the depression group and the control group. Frontal (F3, F4) and temporal (T7, T8) regions showed correlation between STAI-T score and A1, A2, and PCT asymmetry indices.
Conclusion : The results of this study showed that EEG A1, A2, and PCT asymmetry indices can be used as useful indices for depression. Also, it was found that trait anxiety had influence on A1, A2, and PCT asymmetry indices.

참고문헌 (Reference)

1 "guide-lines for standard electrode position nomenclature" 111-13,

2 "Vali-dity of zungs self-rating depression scale: Detection of depression in primary care" 21 : 1317-1330, 2000

3 "The relation-ship between frontal EEG asymetry and the risk for anxiety and depression" 74 : 26-33, 2006

4 "The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)" 289 : 3095-3105, 2003

5 "The clinical use of an alpha asym-metry biofeedback protocol in treatment of depressive disorders: two case studies" 2 : 12-27, 1998

6 "Task-dependent EEG asym-metry discriminates between depressed and nondepressed subjects"

7 "Subgenual prefrontal cortex abnormalities in mood disorders" 386 : 824-827, 1997

8 "STAI의 한국 표준화에 관한 연구" 69-75,

9 "Regional electroencepha-lographic asymmetries in bipolar seasonal affective disorder before and after exposure to bright light" 642-646, biolpsychiatry1993;33

10 "Regional brain metabolic changes in patients with major depression treated with either paroxetine or interpersonal therapy: Preliminary fin-dings" 58 : 631-640, 2001

11 "Regional brain function in sadness and depression" New York: Oxford University Pres 269-297, 2000

12 "Regional brain electrical asymmetries discriminate between previously depressed and healthy control subjects" 22-31, jabnormpsychol1990;99

13 "Regional brain activity in emotion: A framework for understanding cognition in depression" 11 : 637-661, 1997

14 "Regio-nal brain asymmetries in major depression with or without an anxiety disorder: A quantitative electroencephalographic study" 41 : 939-948, 1997

15 "Preliminary evidence that daily changes in frontal alpha asymetry corelate with changes in affect in therapy sessions" 23 : 137-141, 1996

16 "Patterns of perceptual asymmetry in depression and anxiety: Implications for neuropsychological models of emotion and psychopathology" 104 : 327-333, 1995

17 "Mannual for the state-trait anxiety inventory" Consulting Psycho-logists Press;1970

18 "Left frontal hypoactivation in depression" 535-545, jabnormalpsychol1991;100

19 "Electrical activity of the brain Handbook of Psychophysiology" 263-328,

20 "EEG alpha asymmetry, depre-ssion, and cognitive functioning" 12 : 449-478, 1998

21 "Diagnostic and statistical manual of mental disorders: DSM-IV." Washington DC: American Psychi-atric Association 2000

22 "Comparison of two EEG asymmetry indices in depressed patients vs. normal controls" 31 : 89-92, 1998

23 "Can EEG asymmetry pattern predict future development of anxiety and depression? A preliminary study" 72 : 46-50, 2006

24 "Anxiety syndromes and their relationship to depressive illness" 8-11, jclinpsychiatry1983;44

25 "An inventory for measuring depression" 561-571,

26 "A study of the reliability and the validity of the BDI" 98-113, koreanjclinpsychology1991;15

27 "A rating scale for depression" 56-62, jneurolneurosurgpsy-chiatry1960;23