만성 이황화탄소중독의 신증상과 신조직검사 소견에 대한 연구 = Renal Symptoms and Kidney Biopsy Findings of Chronic CS₂ Intoxication

다국어 초록 (Multilingual Abstract)

Carbon disulfide(CS₂), a volatile gas used during the processing of viscose rayon synthesis, is known to be a neurotoxin and to cause atherogenesis in the vascular system.
This atherogenic effect is thought to be responsible for the renal impairment caused by chronic CS₂ intoxication.
The author hereby reports the renal symptoms and kidney biopsy findings of 21 cases of chronic CS₂ intoxication.
1) A total of 21 patients, 16 males and 5 females, with a history of working at a rayon factory were examined. The mean age was 44.4±5.2 years old, and the duration of exposure was 13.4±4.0 years.
2) Of the total 21 cases, four patients were hypertensive and another four had proteinuria. Two of those patients also had azotemia.
3) In kidney biopsy, light microscopy revealed diffuse or nodular glomerular sclerosis in eight cases. Immunoflurorescence microscopy revealed nonspecific focal deposits of C3 and IgM in four cases. Electron microscopy revealed that the basement membranes were significantly thicker with a mean of 656.9±244.7㎚ than the normal thickness(320±10㎚).
4) The above results suggest that kidney biopsy is helpful in the early diagnosis of chronic CS₂ intoxication and that the histologic findings are similar to those of diabetes mellitus.