남성형 탈모증 환자의 탈모부와 비탈모부에서의 안드로켄 수용체와 에스트로겐 수용체의 발현에 관한 연구 = The Expressions of Androgen Receptors and Estrogen Receptors in Bald and Non-bald Area of Androgeaic Alopecia남성형 탈모증 환자의 탈모부와 비탈모부에서의 안드로켄 수용체와 에스트로겐 수용체의 발현에 관한 연구

다국어 초록 (Multilingual Abstract)

Background : Androgenic alopecia, commonly known in men as male pattern baldness is the gradual balding of the scalp in response to androgens in genetically predisposed individuals. Androgens can gradually transform large scalp hair follicles to smaller vellus ones, causing balding. The mechanisms involved are unclear, although androgens are believed to act on the epithelial hair follicle via the mesenchymal derived dermal papilla. During pregnancy, hair growth is increased, as estrogen appears to prolong the anagen phase, and postpartum hair loss may be related to a rapid decrease in estrogen. Objective : The aim of the present study was to evaluate the difference of the expressions of androgen receptors(AR) and estrogen receptors(ER) by monoclonal antibodies in biopsy specimens between bald area and non-bald area. Methods : Immunohistochemical analysis of Ah and ER receptor were preformed on the paraffine-embedded tissue sections of bald area and non-bald area in ６ cases of androgenic alopecia using anti-AR and anti-ER monoclonal antibodies with avidin-biotin peroxidase complex procedure. Results : The results were that androgen receptors were higher level in bald area and estrogen receptors showed no difference between bald and non-bald area. Conclusion : This study supports that locally increased androgen activities may be related with hair loss in androgenic alopecia and estrogens have less relationship in the pathogenesis of androgenic alopecia. (Korean J Dermatol ２００２:４０(１２) : １４８７∼１４９２)