규칙적인 운동과 타우린 투여가 seizure 유발 쥐 해마의 nNOS, NGF, BDNF에 미치는 영향 = The effect of regular exercise and taurine supplementation on nNOS, NGF and BDNF of hippocampus in seizure induced mice model

다국어 초록 (Multilingual Abstract)

The purpose of this study is to find out the effect of regular aerobic exercise and taurine supplementation on nNOS, NGF and BDNF protein revelation variety of hippocampus in induced seizure. For the study, 36 white mice of ICR species were divided into four groups: the control group, the exercise group, the taurine supplemented group and taurine supplemented-exercise group, after the swimming exercise for 8 week, all groups injected PTZ (35-40mg/kg) to seizure induced. After the period, a brain cell injury was analyzes through seizure activity, mortality, nNOS, NGF and BDNF. The result showed that a brain cell injury was facilitated when seizure activity increased. However, it was found that performing regular exercise, taurine supplementation and exercise combined taurine reduced seizure activity, increased NGF and BDNF, decreased nNOS so that it suppress brain cell injury. This results suggested that combined treatment of swimming exercise and taurine supplementation might give a benefical effect on suppress seizure and decreased nNOS, increased revelation NGF and BDNF.

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