12주간의 복합운동 처치가 비만 여대생의 혈중 산화적 스트레스 지표, 신경영양인자 및 기분상태척도(POMS) 변화에 미치는 영향

다국어 초록 (Multilingual Abstract)

The purpose of this study was to investigate the effects of combined exercise on oxidative stress, neurotrophin and Profile of Mood States(POMS). The subjects for this study were 22 obese college females who had more than 30% of body fat and they were randomly divided into control group(Con, n=12) and exercise group(Ex, n=10). During exercise training for 12 weeks, resistance exercise of 8 events was conducted with 80% of 1-RM by circuit weight training method and aerobic exercise conducted treadmill walking and/ or running for 30 minutes. Blood samples were taken at before combined exercise(Pre) and at after combined exercise(Post). For oxidative stress, the malondealdehyde(MDA) level was shown to significantly increase at Post in Ex(p<.05) while the superoxide dismutase(SOD) activity was shown to significantly decrease at Post in Ex(p<.05). For neurotrophins, the BDNF and NGF levels were shown to significantly increase at Post in Ex(p<.05). For POMS, Depression-Dejection(D-D) score was shown to significantly decrease at Post in Ex(p<.05). On the base of the results of the this study, it is suggested that combined exercise can induce decrease levels of oxidative stress and increase levels of neurotrophins which may positively influence on the POMS depression subscale.

목차 (Table of Contents)

• Ⅰ. 서론
• Ⅱ. 연구방법
• Ⅲ. 결과
• Ⅳ. 논의
• Ⅴ. 결론 및 제언
• 참고문헌
• ABSTRACT

참고문헌 (Reference)

1 김의중, "한국판 기분상태척도(K-POMS)의 표준화와 신뢰도와 타당도 평가" 10 (10): 39-51, 2003

2 우진희, "트레드밀 트레이닝이 비만 쥐의 neurotrophins와 초기발현 단백질에 미치는 영향" 한국생명과학회 21 (21): 985-991, 2011

3 정길수, "여대생의 비만도, 체지방율, 신체상 및 우울에 관한 연구" 29-30, 2003

4 손연정, "성인 여성의 비만, 자존감과 우울증상 간의 관계" 대한비만학회 21 (21): 89-98, 2012

5 김철식, "빠르게 걷기운동프로그램이 비만여성의 체질량지수, 체지방률 및 기분상태에 미치는 효과" 13 (13): 132-140, 2004

6 김현준, "비만여성의 규칙적인 운동과 운동 강도가 MDA와 SOD 활성에 미치는 영향" 한국발육발달학회 13 (13): 51-61, 2005

7 보건복지부, "비만바로알기"

8 신석민, "복합운동이 과체중 및 비만청소년의 신체구성, 혈중지질 및 BDNF에 미치는 영향" 한국생명과학회 22 (22): 1231-1236, 2012

9 채창훈, "당뇨 쥐 해마에서 운동을 통한NGF 발현증가 및 세포사멸 억제효과" 179-, 2009

10 Zender, R., "Women’s mental health : depression and anxiety" 44 (44): 355-364, 2009

11 Bansi, J., "Training in MS : influence of two different endurance training protocols(aquatic versus overland)on cytokine and neurotrophin concentrations during three week randomized controlled trial" 19 (19): 613-621, 2013

12 Radak, Z., "The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain" 49 (49): 387-392, 2006

13 Kimpton, J., "The brain derived neurotrophic factor and influences of stress in depression" 24 (24): 169-171, 2012

14 Anand, S.S., "Stemming the global tsunami of cardiovascular disease" 377 (377): 529-532, 2011

15 El-Gharbawy, A. H., "Serum brain-derived neurotrophic factor concentrations in lean and overweight children and adolescents" 91 (91): 3548-3552, 2006

16 Ghosh, S., "Selecting exercise regimens and strains to modify obesity and diabetes in rodents : an overview" 119 (119): 57-74, 2010

17 McNair, D. M., "Profile of mood states manual"

18 Ang, E.T., "Potential therapeutic effects of exercise to the brain" 14 (14): 2564-2571, 2007

19 Umpierre, D., "Physical activity advice only or structured exercise training and association with HbA1c levels in type 2 diabetes : a systematic review and meta-analysis" 305 (305): 1790-1799, 2011

20 Urso, M.L., "Oxidative stress, exercise, and antioxidant supplementation" 189 (189): 41-54, 2003

21 Luppino, F. S., "Overweight, obesity, and depression : a systematic review and meta-analysis of longitudinal studies" 67 (67): 220-229, 2010

22 WHO, "Obesity: preventing and managing the global epidemic. Report of a WHO consultation" World Health Organ 1-12, 2000

23 Azarbad, L., "Obesity in women" 33 (33): 423-440, 2010

24 Higdon, J.V., "Obesity and oxidative stress: a direct link to CVD?" 23 (23): 365-367, 2003

25 Moretto, M., "Nitric oxide regulates luteinizing hormone-releasing hormone secretion" 133 (133): 2399-2402, 1993

26 Yasin, S., "Nitric oxide modulates the release of vasopressin from rat hypothalamic explants" 133 (133): 1466-1469, 1993

27 Nikulina, E. M., "Neurotrophins in the ventral tegmental area : Role in social stress, mood disorders and drug abuse" 282 : 122-138, 2014

28 Alberch, J., "Neurotrophic factors in Huntington’s disease" 146 : 195-229, 2004

29 Lin, M.T., "Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases" 443 (443): 787-795, 2006

30 Gago-Dominguez, M., "Lipid peroxidation, oxidative stress genes and dietary factors in breast cancer protection : a hypothesis" 9 (9): 1-11, 2007

31 Chao, C. C., "Integrin alphav and NCAM mediate the effects of GDNF on DA neuron survival, outgrowth, DA turnover and motor activity in rats" 24 (24): 105-116, 2003

32 Furukawa, S., "Increased oxidative stress in obesity and its impact on metabolic syndrome" 114 (114): 1752-1761, 2004

33 Ozcelik, O., "Exercise training as an adjunct to orlistat therapy reduces oxidative stress in obese subjects" 206 (206): 313-318, 2005

34 Araya, A. V., "Effect of exercise on circulating levels of brain-derived neurotrophic factor(BDNF)in overweight and obese subjects" 45 (45): 541-544, 2013

35 Bulló, M., "Circulating nerve growth factor levels in relation to obesity and the metabolic syndrome in women" 157 (157): 303-310, 2007

36 Heyer, N. J., "Chronic low-level mercury exposure, BDNF polymorphism, and associations with self-reported symptoms and mood" 81 (81): 354-363, 2004

37 Keddie, A.M., "Associations Between Severe Obesity and Depression : Results From the National Health and Nutrition Examination Survey, 2005-2006" 8 (8): 1-10, 2011

38 ACSM, "ACSM’s guidelines for exercise testing and prescription" Lippincott williams & wilkins 2006

39 Lopresti, A. L., "A review of peripheral biomarkers in major depression : the potential of inflammatory and oxidative stress biomarkers" 48 : 102-111, 2014

40 보건복지부, "2011 국민건강 통계"