Parkinson's disease : present status and research trends

목차 (Table of Contents)

• CONTENTS
• PART Ⅰ Clinical Aspects of Parkinson's Disease
• Epidemiology = 3
• Natural History = 4
• Pathology = 4
• Symptoms = 5
• Posture = 5
• Hypothermia = 5
• Speech = 6
• Psychological Factors = 6
• Encephalographic Abnormalities = 7
• Association of Parkinsonism with Other Disorders = 7
• Drug Induced Extrapyramidal Disorders = 8
• Clinical Biochemical Investigations in Parkinsonian Subjects = 8
• Clinical Neurophysiology = 9
• Therapy of Parkinsonism = 11
• Drug Therapy = 11
• Surgical Treatment = 15
• General Assessment of Surgical Results = 15
• Stereotaxic Techniques = 16
• Target Localization = 17
• Mortality = 18
• Complications = 19
• The Effect of Surgery on Individual Symptoms = 19
• 1. General Functional Ability = 19
• 2. Tremor and Rigidity = 19
• 3. Akinesia = 20
• 4. Gait = 20
• 5. Balance = 20
• 6. Alleviation of Muscle Pain = 21
• 7. Limb and Truncal Postural Deformities = 21
• 8. Sialorrhea and Other Vegetative Functions = 21
• 9. Eye Signs = 21
• 10. Vestibular Responses = 21
• 11. Speech = 21
• 12. Psychological and Mental Changes = 22
• 13. Spatial Perception = 23
• 14. Pyramidal Tract Signs = 24
• 15. Abnormal Movements = 24
• 16. Sensory Function = 24
• 17. Swallowing Difficulty = 24
• 18. Urinary Retention = 24
• 19. Peptic Ulcer = 24
• 20. Pulmonary Function = 25
• 21. Electroencephalography : Cortical and Depth Electrode Studies = 25
• Evoked Potential Studies = 26
• Intra- and Extracellular Unit Recordings = 27
• Spinal Reflex Studies = 28
• Stereotaxic Surgery in Other Conditions = 29
• Bibliography = 33
• PART Ⅱ Basic Science Aspects of Parkinson's Disease - Biochemistry
• Neurobilogy of Monoamines = 47
• 1. Aminergic pathways in the CNS = 48
• a. Fluorescence Histochemistry Technique = 48
• Dopamine-containing Neurons in Rat Brain = 48
• NE-containg Neurons in Rat Brain = 49
• Serotonin-containing Neurons in Rat Brain = 49
• b. Biochemical Changes Following Brain Lesions = 50
• 2. Subcellular Distribution of DM = 51
• 3. Embryology of the Monoamine-Storage Sites = 53
• Synthesis and Metabolism of Monoamines = 53
• 1. Biosynthesis of Catecholamines in Brain = 53
• 2. Biosynthesis of Serotonin in Brain = 54
• 3. Fate of the Catecholamines and Serotonin = 54
• 4. Dynamic Equilibrium of DM Stores = 55
• Physiological Role of Brain DM = 56
• Evidence for a Link between Cholinergic and Dopaminergic Function in Basal Ganglia = 58
• Drugs Affecting Brain Dopamine Turnover = 58
• Neuromelanin = 59
• Correlations of Experimental Lesions of the Substantia Nigra and Parkinson's Disease = 60
• Other Chemical Changes in Parkinson's Disease = 60
• Amino Acids and Proteins = 60
• Histamine and Antihistaminies = 61
• Bibliography = 63
• PART Ⅲ Basic Science Aspects of Parkinson's Disease - Physiology
• Basal Ganglia = 73
• Cerebello - Thalamo - Corticospinal Projection System = 78
• Muscle spindles and Segmental Spinal Organization = 85
• Cerebellum = 87
• Bibliography = 91