자궁경부의 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, p53 및 E-cadherin 발현양상 = Association of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression in cervical intraepithelial neoplasia and squamous cell carcinoma

다국어 초록 (Multilingual Abstract)

Background and Objectives: Correlation of cyclin E, bcl-2, p27, VEGF, p53 and E-cadherin expression was analyzed in cervical intraepithelial neoplasia (CIN), carcinoma in situ (CIS), and microinvasive and invasive squamous cell carcinoma (SCC) according to human papilloma virus (HPV) inffection. Materials and Methods : (23 CIN 1, 28 CIN 2, 23 CIN 3), 18 CIS, and 24 SCC. Results: Expression of cyclin E was significantly higher in CIN 2, CIN 3, CIS and SCC than CIN 1 with or without HPV infection. Expression of bcl-2 was significantly higher in CIN 3 than SCC. There was no association between expression of p27 and VEGF and progression of CIN 1 to SCC. Expression of p53 was significantly high in CIN 3, CIS and SCC with or without HPV infection. Expression of the E-cadherin was significantly high in CIN 2, CIN 3, CIS and SCC with or without HPV infection. Conclusion: There was correlation between expression of cyclin E, b치-2, ㅔ53, E-cadherin and progression of CIN to SCC. It is suggested that cyclin E may play an important role in the neoplastic transformation of cervical squamous cell.

목차 (Table of Contents)

• 서론
• 재료 및 방법
• 1. 연구재료
• 2. 연구 방법
• 가. 병리조직학적 검색
• 나. 면역조직화학염색
• 다. HPV 검색
• 라. 통계학적 분석
• 연구 결과
• 1. 자궁경부 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, P53과 E-cadherin 발현 (Table 1)
• 2. HPV에 감염된 자궁경부 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, p53과 E-cadherin 발현 (Table 2)
• 3. HPV에 감염 되지 않은 자궁경부 상피내종양과 편평세포암종에서 cyclin E, bcl-2, p27, VEGF, p53과 E-cadherin 발현 (Table 3)
• 고찰
• 결론