Alcohol의 투여에 따른 쥐의 장기에서 생성되는 과산화물의 정량에 관한 연구 = Studies on Quantitatives of Hydroperixide Formed in Rats Body Intake Some Alcohol

국문 초록 (Abstract)

Sprague-Dawley rat 16마리를 control group, 25% alcohol-dose group, 40% whisky-dose group의 각각 6마리씩으로 나누어 식이하여 다음과 같은 결과를 얻었다.
혈청에서 지방의 분석을 total lipid, triacylglycerol, total cholesterol의 3가지를 측정한 결과, total lipid와 triacylglycerol은 alcohol-dose group, whisky-dose group 모두 contrlo에 비해 높은 값이 나타난 반면, total chloesterol의 양은 별 차이를 보이지 않았다. 장기의 중량을 측정함에 있어 liver에서만 유의하게(ㅔ0.05) whisky-dose group에서 높았다.
TBA에 의한 hydroperoxide 측정은 liver, brain, lung, kidney, tetis brain 경우엔 whisky-dose group에서 증가하였고, lung의 경우에는 오히려 control group에서 높은 값을 보였다.

다국어 초록 (Multilingual Abstract)

Three groups of Sprague-Dawley rats(control,25% alcohol-dose, 40% whisky-dose) were used in this experiments. In plasma, the amounts of total lipid and triacylglycerol in the alcohol-dose and whisky-dose groups were increased than that of control groups. Relative weight of kidney, spleen testis was not affected by alcohol-dose and whisky-dose groups, but that of liver was significantly(p<0.05) increased in the 40% whisky dose group.
The amounts of lipid peroxide in liver, kidney, testis tended to be increased in 25% alcohol dose groups, but not in lung and brain. In lung, the value of malondialdehyde(2nd product of hydroperoxide) of alcohol-dose groups was lowr than control groups, and in brain it was a little more increased in higher concentration of alcohol. The value of hydroperoxide of alcohol groups in the rat liver was significantly(p<0.01) increased compared with the control groups.
There was a significant relation between alcohol consumption and lipid oxidation. Alcohol diet to the rat caused increased of lipid content and peroxidation.