The Role of High Mobility Group Box 1 in Innate Immunity

다국어 초록 (Multilingual Abstract)

With growing accounts of inflammatory diseases such as sepsis, greater understandingthe immune system and the mechanisms of cellular immunity have become primaryobjectives in immunology studies. High mobility group box 1 (HMGB1) is a ubiquitous nuclear protein that is implicated in various aspects of the innate immune system as a damage-associated molecular pattern molecule and a late mediator of inflammation, as well as in principal cellular processes, such as autophagy and apoptosis. HMGB1 functions in the nucleus as a DNA chaperone; however, it exhibits cytokine-like activity when secreted by injurious or infectious stimuli. Extracellular HMGB1 acts through specific receptors to promote activation of the NF-κB signalingpathway, leading to production of cytokines and chemokines. These findings furtherimplicate HMGB1 in lethal inflammatory diseases as a crucial regulator of inflammatory,injurious, and infectious responses. In this paper, we summarize the role of HMGB1 in inflammatory and non-inflammatory states and assess potential therapeuticapproaches targeting HMGB1 in inflammatory diseases.

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