Potassium cyanate에 의해 조절되는 사람 대장암 세포의 방사선 감수성 변화 = Radio-sensitivity of Human Colorectal Cancer Cell is Regulated by Potassium Cyanate

다국어 초록 (Multilingual Abstract)

Potassium cyanate (KCN) is an inorganic reagent and can induce the post-translation carbamylation of proteins. The carbamylated reaction in the body is involved in cell death in various diseases. According the results in our previous study, KCN enhances the radiosensitivity of human colorectal cancer cell line, HCT 116 cells. However, it was not enough to confirm the mechanism that KCN works in these cells. To determinated the mechanisms of KCN in the cells with increased radiosensitivity, HCT 116 cells were treated KCN with low-dose gamma-radiation. And then, we examined alteration of the cell cycle, cell proliferation, cytokine level and the activation of cell signaling protein. As a result, cell cycle arrest and cell death were induced by the activation of caspase-3 and PARP in the irradiated cells with KCN treatment. These changes of the irradiated cell with KCN treatment were induced by the release of TNF-α via NF-κB activation. In conclusions, enhanced radio-sensitivity mediated by KCN induced cell death and it occurs by NF-κB-dependent TNF-α production.

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