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      KCI등재

      Potassium cyanate에 의해 조절되는 사람 대장암 세포의 방사선 감수성 변화 = Radio-sensitivity of Human Colorectal Cancer Cell is Regulated by Potassium Cyanate

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      https://www.riss.kr/link?id=A106098432

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      다국어 초록 (Multilingual Abstract)

      Potassium cyanate (KCN) is an inorganic reagent and can induce the post-translation carbamylation of proteins. The carbamylated reaction in the body is involved in cell death in various diseases. According the results in our previous study, KCN enhances the radiosensitivity of human colorectal cancer cell line, HCT 116 cells. However, it was not enough to confirm the mechanism that KCN works in these cells. To determinated the mechanisms of KCN in the cells with increased radiosensitivity, HCT 116 cells were treated KCN with low-dose gamma-radiation. And then, we examined alteration of the cell cycle, cell proliferation, cytokine level and the activation of cell signaling protein. As a result, cell cycle arrest and cell death were induced by the activation of caspase-3 and PARP in the irradiated cells with KCN treatment. These changes of the irradiated cell with KCN treatment were induced by the release of TNF-α via NF-κB activation. In conclusions, enhanced radio-sensitivity mediated by KCN induced cell death and it occurs by NF-κB-dependent TNF-α production.
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      Potassium cyanate (KCN) is an inorganic reagent and can induce the post-translation carbamylation of proteins. The carbamylated reaction in the body is involved in cell death in various diseases. According the results in our previous study, KCN enhanc...

      Potassium cyanate (KCN) is an inorganic reagent and can induce the post-translation carbamylation of proteins. The carbamylated reaction in the body is involved in cell death in various diseases. According the results in our previous study, KCN enhances the radiosensitivity of human colorectal cancer cell line, HCT 116 cells. However, it was not enough to confirm the mechanism that KCN works in these cells. To determinated the mechanisms of KCN in the cells with increased radiosensitivity, HCT 116 cells were treated KCN with low-dose gamma-radiation. And then, we examined alteration of the cell cycle, cell proliferation, cytokine level and the activation of cell signaling protein. As a result, cell cycle arrest and cell death were induced by the activation of caspase-3 and PARP in the irradiated cells with KCN treatment. These changes of the irradiated cell with KCN treatment were induced by the release of TNF-α via NF-κB activation. In conclusions, enhanced radio-sensitivity mediated by KCN induced cell death and it occurs by NF-κB-dependent TNF-α production.

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      참고문헌 (Reference)

      1 S. Busquets, "Tumor necrosis factor-alpha uncouples respiration in isolated rat mitochondria" 22 (22): 1-4, 2003

      2 D. Blumberg, "Treatment of colon and rectal cancer" 34 (34): 15-26, 2002

      3 장정현, "The Effect of Potassium Cyanate (KCN) on Radiation Treatment of the Colorectal Cancer Cell Line, HCT 116" 대한의생명과학회 19 (19): 98-104, 2013

      4 양은주, "TNF-α Regulates Potassium Cyanate-induced Apoptosis via NF-κB Activation in HCT 116 Cells" 대한의생명과학회 20 (20): 32-38, 2014

      5 V. K. Mehta, "Radiotherapy, concomitant protracted-venous-infusion 5-fluorouracil, and surgery for ultrasound-staged T3to T4 rectal cancer" 44 (44): 52-58, 2001

      6 양은주, "Potassium Cyanate Induces Apoptosis of Human Colorectal Cancer Cell via Mitochondrial Pathway" 대한의생명과학회 17 (17): 177-184, 2011

      7 T. L. Henriette, "Pharmacogenetics in chemotherapy of colorectal cancer" 23 (23): 257-273, 2009

      8 T. E. Read, "Neoadjuvant therapy for adenocarcinoma of the rectum : tumor response and acute toxicity" 44 (44): 513-522, 2001

      9 C. L. Kuckel, "Methylisocyanate and actin polymerization: The in vitro effects of carbamylation" 1162 (1162): 143-148, 1993

      10 H. Bouzourene, "Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy" 94 (94): 1121-1130, 2002

      1 S. Busquets, "Tumor necrosis factor-alpha uncouples respiration in isolated rat mitochondria" 22 (22): 1-4, 2003

      2 D. Blumberg, "Treatment of colon and rectal cancer" 34 (34): 15-26, 2002

      3 장정현, "The Effect of Potassium Cyanate (KCN) on Radiation Treatment of the Colorectal Cancer Cell Line, HCT 116" 대한의생명과학회 19 (19): 98-104, 2013

      4 양은주, "TNF-α Regulates Potassium Cyanate-induced Apoptosis via NF-κB Activation in HCT 116 Cells" 대한의생명과학회 20 (20): 32-38, 2014

      5 V. K. Mehta, "Radiotherapy, concomitant protracted-venous-infusion 5-fluorouracil, and surgery for ultrasound-staged T3to T4 rectal cancer" 44 (44): 52-58, 2001

      6 양은주, "Potassium Cyanate Induces Apoptosis of Human Colorectal Cancer Cell via Mitochondrial Pathway" 대한의생명과학회 17 (17): 177-184, 2011

      7 T. L. Henriette, "Pharmacogenetics in chemotherapy of colorectal cancer" 23 (23): 257-273, 2009

      8 T. E. Read, "Neoadjuvant therapy for adenocarcinoma of the rectum : tumor response and acute toxicity" 44 (44): 513-522, 2001

      9 C. L. Kuckel, "Methylisocyanate and actin polymerization: The in vitro effects of carbamylation" 1162 (1162): 143-148, 1993

      10 H. Bouzourene, "Importance of tumor regression assessment in predicting the outcome in patients with locally advanced rectal carcinoma who are treated with preoperative radiotherapy" 94 (94): 1121-1130, 2002

      11 R. Fluckiger, "Hemoglobin carbamylation in uremia" 304 (304): 823-827, 1981

      12 E. O. Apostolov, "Endonuclease G mediates endothelial cell death induced by carbamylated LDL" 300 (300): H1997-H2004, 2011

      13 K. Schulze-Osthoff, "Cytotoxic activity of tumor necrosis factor is mediated by early damage of mitochondrial functions. Evidence for the involvement of mitochondrial radical generation" 267 (267): 5317-5323, 2005

      14 E. OK, "Carbamylated low-density lipoprotein induces death of endothelial cells : A link to atherosclerosis in patients with kidney disease" 68 (68): 173-178, 2005

      15 L. M. Kraus, "Carbamoylation of amino acids and proteins in uremia" 78 : S102-S107, 2001

      16 E. N. Inoue, "Bimodal effects of platelet-derived growth factor on rat mesangial cell proliferation and death, and the role of lysophosphatidic acid in cell survival" 101 (101): 11-19, 2001

      17 P. G. Rychahou, "Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis" 105 (105): 20315-20320, 2008

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 선정 (계속평가) KCI등재
      2016-01-01 평가 등재후보학술지 유지 (계속평가) KCI등재후보
      2015-01-01 평가 등재후보학술지 유지 (계속평가) KCI등재후보
      2013-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2012-01-01 평가 등재후보학술지 유지 (기타) KCI등재후보
      2011-02-28 학술지명변경 한글명 : 한국방사선학회 논문지 -> 한국방사선학회논문지 KCI등재후보
      2010-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
      2008-01-24 학회명변경 한글명 : 방사선학회 -> 한국방사선학회
      영문명 : The Society of Radiology -> The Korea Society of Radiology
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.28 0.28 0.36
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.37 0.37 0.452 0.05
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