류마티스 관절염 환자에서 Bucillamine이 모발 미세원소 농도에 미치는 영향 = The Effect of Bucillamine of Trace Element Levels of Hair in Patients with Rheumatoid Arthritis

다국어 초록 (Multilingual Abstract)

Objectives: We investigated the changes of trace element levels in hair of patients with rheumatoid arthritis after bucillamine treatment. Methods: We performed inductively coupled plasma atomic emission spectrometry in determination of trace element levels in hair of patients with rheumatoid arthritis. Results: The results were as follows: 1) There was a significant increase of copper concentration, but no change in zinc level after bucillamine treatment. 2) There were no significant changes in copper and zinc concentrations between the proximal and distal portions of hair after long-term bucillamine treatment. Conclusions: Our results showed the significant increase of copper level and no significant change of zinc level in hair after bucillamine treatment, but, although statistically not significant, copper and zinc levels were decreased on experiment with divided hair. So, our findings do not permit any conclusion on the influence of bucillamine on trace element levels in hair. Further studies in large samples and comparison with the effect of D-penicillamine will be necessary to clarify the association of trace element levels in hair of rheumatoid arthritis patients and bucillamine treatment.