Different Function of Two Ubiquitin C-Terminal Hydrolase Isozymes in Mouse Kidney

다국어 초록 (Multilingual Abstract)

The ubiquitin-proteasome system is associated with homeostasis and several biological processes. The level of ubiquitin-proteasome system is regulated by deubiquitinating enzymes. Deubiquitinating enzymes are subdivided into ubiquitin C-terminal hydrolases (UCH) and ubiquitin-specific proteases. Previous studies show that UCH isozymes have critical function during neurogenesis and spermatogenesis, whereas UCH function has been limited in kidney. We demonstrated different levels and expressions of the UCH-L1 and UCH-L3, such as the predominant expression of UCH-L1 in renal papilla whereas UCHL3 expression was high in the renal medulla and cortex. These results suggest that different distributions of two UCH isozymes may indicate the distinct functions in mouse nephrology.

참고문헌 (Reference)

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