Lewis Acid 촉매를 이용한 N-Hydroxysuccinimide의 실용적 합성법 연구 = Practical Synthesis of N-Hydroxysuccinimide Using Lewis Acid Catalyst

국문 초록 (Abstract)

정밀화학 및 화장품 산업에서 널리 사용되는 N-hydroxysuccinimide (NHS)의 새로운 실용적 합성법을 개발하였다. 기존합성법은 무수 숙신산과 NH2OH 반응 후 강산을 촉매로 약 70%의 수율로 NHS를 얻는다. 이 방법은 무수 숙신산을 사용하여 비교적 쉽게 NHS를 얻을 수 있는 장점이 있으나 비싼 무수 숙신산을 사용하기 때문에 전혀 경제적이지 않다. 이런 단점을 극복하기 위해서 본 연구에서는 무수 숙신산 대신에 저렴한 숙신산과 Lewis 산인 Zinc acetate를 촉매로 사용하여 80%의 높은 수율로 NHS를 제조하는 새로운 경제적인 합성법을 개발하였으며 경제성 평가 결과 약 15%의 원가 절감 효과가 있음을 확인하였다.

다국어 초록 (Multilingual Abstract)

A new synthetic method for N-hydroxysuccinimide (NHS), which is widely used in fine chemical and cosmetic industries, was developed. In a conventional synthesis, NHS is obtained by reacting NH2OH with succinic anhydride in a yield of about 70% using strong acid as a catalyst, which has an advantage of obtaining NHS relatively easily. However, it is expensive because of using a high cost succinic anhydride. In order to overcome this issue, we developed a new synthetic method for NHS with a moderate yield of 80% using a low cost succinic acid instead of succinic anhydride, alongside a stable Lewis acid catalyst, Zn acetate. As a result of the economic evaluation, it was confirmed that the cost reduction effect was about 15%.

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