백서 태자 창상치유에서의 세포반응과 교원질의 침착양상에 대한 조직학적 연구 = HISTOLOGICAL STUDIES ON THE CELLULAR REACTION AND COLLAGEN DEPOSITION OF THE FETAL WOUND HEALING IN RATS

다국어 초록 (Multilingual Abstract)

Fetal diagnosis has undergone explosive growth in the past decade. As a result of antenatal diagnosis, the fetus is now considered as a patient. Recent experimental work supports Rowlatt's clinical observation that the midgestational human fetus heals by mesenchymal proliferation without scar formation normally seen in the adult. Studies using rats, rabbit, sheep, and monkeys demonstrate distinct differences between fetal and adult skin wound healing. However, the nature of these differences remains unknown, and it might be hypothesized that the cellular and connective tissue responses to injury in the fetus are distinctly different from those of the adult.
To directly test this hypotheses, the tissue response to injury was studied in fetal, neonatal, and adult Sprague-Dawley rats using a standard wound model. In the fetus, inflammatory process and granulation tissues were not noted, and no collagen was seen. In neonatal and adult rat, inflammatory process, granulation tissues, and collagen deposition were noted. There was no positive reaction to type III & IV collagen in immunohistochemical stain. Conclusively, we could see the inflammatory reaction and collagen deposition in the neonate and adult wound, and find that fetal wound was repaired without the inflammatory reaction and collagen deposition.