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      SCOPUS KCI등재 SCIE

      정상 성인 여성의 혈중 불소농도 및 불소제제 ( Disodium Monofluorophosphate ) 투여후 혈중 불소농도의 변화 = Serum Fluoride Level in Normal Adult Women and Changes in Serum Fluoride Level after Disodium Monofluorophosphate Administration

      한글로보기

      https://www.riss.kr/link?id=A3201832

      • 저자

        정미선 (성균관대학교 의과대학 삼성제일병원 내분비연구실) ;  민헌기 (성균관대학교 의과대학 삼성제일병원 내과) ;  한인권 (성균관대학교 의과대학 삼성제일병원 내과) ;  장학철 (성균관대학교 의과대학 삼성제일병원 내과) ;  정호연 (성균관대학교 의과대학 삼성제일병원 내과) ;  한기옥 (성균관대학교 의과대학 삼성제일병원 내과) ;  김상우 (성균관대학교 의과대학 삼성제일병원 내과) ;  문인걸 (성균관대학교 의과대학 삼성제일병원 내분비연구실) ;  윤현구 (성균관대학교 의과대학 삼성제일병원 내과)

      • 발행기관
      • 학술지명
      • 권호사항
      • 발행연도

        1997

      • 작성언어

        Korean

      • KDC

        511.000

      • 등재정보

        SCOPUS,KCI등재,SCIE

      • 자료형태

        학술저널

      • 발행기관 URL
      • 수록면

        565-570(6쪽)

      • 제공처
      • 중단사유

        ※ 발행기관의 정책으로 인하여 개인 판매가 중단된 논문입니다. 구독기관 이용자는 [유료 KISS] 홈페이지에서 원문을 이용해 주시기 바랍니다.

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      부가정보

      다국어 초록 (Multilingual Abstract)

      Background: Since the morning fluoride level of 10 uM is recommended for adults patients being treated for osteoporosis so far, measurement of serum fluoride level is important to detect abnormally high levels or to detect levels below the therapeutic windows. Aims of this study are to determine the normal range of serum ionic fluoride levels in Korean female adults (from 5th to 7th decade), and to evaluate the in vivo fluoride pharmacokinetics of monofluorophosphate in Korean adults.
      Methods: Serum level of fluoride was measured from blood samples of 72 female subjects(age 43-69years) using an ion selective electrode. For pharrnacokinetics of monofluorophosphate-calcium(MFP-Ca), 6 subjects(age 27~45 years) were included to be withdrawn the blood hourly for the first S hours and the blood was withdrawn at 24 hours after a single dose of MFP-Ca.
      Results: Mean level of serum fluoride was 1.64+-0.12uM in 5th, 6th, 7th decades adults, and there was no difference of serum fluoride levels among age groups. Peak serum fluoride level exhibited 5.02+-0.67pM, and returned to basal level on 24 hours after a single dose of MFP-Ca.
      Conclusion: This study shows that mean serutn fluoride of Korean female adults(from 5th to 7th decade) is not different from that of other reports, and a single dose of MFP-Ca does not cause serum fluoride levels above the recommended therapeutic windows of 5-10uM for 24 hours. (J Korean Soc Endocrinol 12:565-570, 1997)
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      Background: Since the morning fluoride level of 10 uM is recommended for adults patients being treated for osteoporosis so far, measurement of serum fluoride level is important to detect abnormally high levels or to detect levels below the therapeutic...

      Background: Since the morning fluoride level of 10 uM is recommended for adults patients being treated for osteoporosis so far, measurement of serum fluoride level is important to detect abnormally high levels or to detect levels below the therapeutic windows. Aims of this study are to determine the normal range of serum ionic fluoride levels in Korean female adults (from 5th to 7th decade), and to evaluate the in vivo fluoride pharmacokinetics of monofluorophosphate in Korean adults.
      Methods: Serum level of fluoride was measured from blood samples of 72 female subjects(age 43-69years) using an ion selective electrode. For pharrnacokinetics of monofluorophosphate-calcium(MFP-Ca), 6 subjects(age 27~45 years) were included to be withdrawn the blood hourly for the first S hours and the blood was withdrawn at 24 hours after a single dose of MFP-Ca.
      Results: Mean level of serum fluoride was 1.64+-0.12uM in 5th, 6th, 7th decades adults, and there was no difference of serum fluoride levels among age groups. Peak serum fluoride level exhibited 5.02+-0.67pM, and returned to basal level on 24 hours after a single dose of MFP-Ca.
      Conclusion: This study shows that mean serutn fluoride of Korean female adults(from 5th to 7th decade) is not different from that of other reports, and a single dose of MFP-Ca does not cause serum fluoride levels above the recommended therapeutic windows of 5-10uM for 24 hours. (J Korean Soc Endocrinol 12:565-570, 1997)

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