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      白何首烏 물 추출물의 파골세포 분화에 미치는 영향

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      https://www.riss.kr/link?id=A100310945

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      다국어 초록 (Multilingual Abstract)

      Osteoporotic fracture became a serious social problem, which related with mortality and morbidity in old age population. Osteoclast which is responsible for bone resorption is originated from hematopoietic cell line and plays a key role osteoporotic bone loss. Cynanchum wilfordii (Asclepiadaceae) roots have been used in Korean folk medicine for the treatment of diabetes mellitus and aging progression. Also, recent studies have shown that the extract and fractions of Cynanchi Wilfordii Radix have various pharmacological actions including scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the effect of extract of Cynanchi Wilfordii Radix in osteoclast differentiation had not been reported. Thus, we evaluated the effect of Cynanchi Wilfordii Radix on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. Through our study, we found that Cynanchi Wilfordii Radix significantly inhibited osteoclast differentiation induced by RANKL. Cynanchi Wilfordii Radix suppressed the activation of p38 pathway and NFκB in bone marrow macrophages (BMMs) treated with RANKL. Also, Cynanchi Wilfordii Radix significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase (TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Cynanchi Wilfordii Radix inhibited the protein expression of c-fos and NFATc1. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.
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      Osteoporotic fracture became a serious social problem, which related with mortality and morbidity in old age population. Osteoclast which is responsible for bone resorption is originated from hematopoietic cell line and plays a key role osteoporotic b...

      Osteoporotic fracture became a serious social problem, which related with mortality and morbidity in old age population. Osteoclast which is responsible for bone resorption is originated from hematopoietic cell line and plays a key role osteoporotic bone loss. Cynanchum wilfordii (Asclepiadaceae) roots have been used in Korean folk medicine for the treatment of diabetes mellitus and aging progression. Also, recent studies have shown that the extract and fractions of Cynanchi Wilfordii Radix have various pharmacological actions including scavenging free radicals, enhancing immunity, reducing high serum cholesterol, and anti-tumor activity. However, the effect of extract of Cynanchi Wilfordii Radix in osteoclast differentiation had not been reported. Thus, we evaluated the effect of Cynanchi Wilfordii Radix on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclast differentiation. Through our study, we found that Cynanchi Wilfordii Radix significantly inhibited osteoclast differentiation induced by RANKL. Cynanchi Wilfordii Radix suppressed the activation of p38 pathway and NFκB in bone marrow macrophages (BMMs) treated with RANKL. Also, Cynanchi Wilfordii Radix significantly inhibited the mRNA expression of c-Fos, tartrate-resistant acid phosphatase (TRAP), osteoclast-associated receptor (OSCAR), nuclear factor of activated T cells (NFAT)c1 and cathepsin K in BMMs treated with RANKL. Particularly, Cynanchi Wilfordii Radix inhibited the protein expression of c-fos and NFATc1. Taken together, our results demonstrated that Cynanchi Wilfordii Radix may be useful treatment option of bone-related disease such as osteoporosis leads to fracture of bone and rheumatoid arthritis.

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      참고문헌 (Reference)

      1 오재민, "파골세포 분화에 미치는 복분자 물 추출물의 효과" 대한동의병리학회 25 (25): 669-673, 2011

      2 정연태, "두충의 물 추출물이 파골세포의 분화에 미치는 영향" 대한동의병리학회 23 (23): 613-618, 2009

      3 유주열, "동의사상의학강좌" 대성문화사 414-, 1999

      4 한기선, "白何首烏 항산화활성과 amino acid의 분포에 관한 실험적 연구" 19 (19): 411-430, 1998

      5 Kim, M. S, "Wilfoside K1N isolated from Cynanchum wilfordii inhibits angiogenesis and tumor cell invasion" PROFESSOR D A SPANDIDOS 26 (26): 1533-1539, 200506

      6 Galibert, L, "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling m" 273 : 34120-34127, 1998

      7 Park, C, "The incidence and residual lifetime risk of osteoporosis-related fractures in Korea" 29 (29): 744-751, 2011

      8 Dougall, W. C, "RANK is essential for osteoclast and lymph node development" 13 : 2412-2424, 1999

      9 Lee, M. K, "Protection of rat hepatocytes exposed to CCl4 in-vitro by cynandione A, a biacetophenone from Cynanchum wilfordii" 52 (52): 341-345, 2000

      10 Looker, A, "Prevalence of low femoral bone density in older U.S. women from NHANES III" 10 : 796-802, 1995

      1 오재민, "파골세포 분화에 미치는 복분자 물 추출물의 효과" 대한동의병리학회 25 (25): 669-673, 2011

      2 정연태, "두충의 물 추출물이 파골세포의 분화에 미치는 영향" 대한동의병리학회 23 (23): 613-618, 2009

      3 유주열, "동의사상의학강좌" 대성문화사 414-, 1999

      4 한기선, "白何首烏 항산화활성과 amino acid의 분포에 관한 실험적 연구" 19 (19): 411-430, 1998

      5 Kim, M. S, "Wilfoside K1N isolated from Cynanchum wilfordii inhibits angiogenesis and tumor cell invasion" PROFESSOR D A SPANDIDOS 26 (26): 1533-1539, 200506

      6 Galibert, L, "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling m" 273 : 34120-34127, 1998

      7 Park, C, "The incidence and residual lifetime risk of osteoporosis-related fractures in Korea" 29 (29): 744-751, 2011

      8 Dougall, W. C, "RANK is essential for osteoclast and lymph node development" 13 : 2412-2424, 1999

      9 Lee, M. K, "Protection of rat hepatocytes exposed to CCl4 in-vitro by cynandione A, a biacetophenone from Cynanchum wilfordii" 52 (52): 341-345, 2000

      10 Looker, A, "Prevalence of low femoral bone density in older U.S. women from NHANES III" 10 : 796-802, 1995

      11 Shimizu, H, "NFkappaB decoy oligodeoxynucleotides ameliorates osteoporosis through inhibition of activation and differentiation of osteoclasts" 13 (13): 933-941, 2006

      12 Takayanagi, H, "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts" 3 : 889-901, 2002

      13 Shan, L, "Gastroprotective effect of a traditional Chinese herbal drug “Baishouwu" on experimental gastric lesions in rats" 107 : 389-394, 2006

      14 Cummings, S. R, "Endogenous hormones and the risk of hip and vertebral fractures among older women. Study of Osteoporotic Fractures Research Group" 339 : 733-738, 1998

      15 Korczowska, I, "Does low-dose and short-term glucocorticoids treatment increase the risk of osteoporosis in rheumatoid arthritis female patients?" 27 (27): 565-572, 2008

      16 Lee, M. K, "Cynandione A from Cynanchum wilfordii protects cultured cortical neurons from toxicity induced by H2O2, L-glutamate, and kainate" 59 (59): 259-264, 2000

      17 YanFu Jiang, "Chemical Constituents of Cynanchum wilfordii and the Chemotaxonomy of Two Species of the Family Asclepiadacease, C. wilfordii and C. auriculatum" 대한약학회 34 (34): 2021-2027, 2011

      18 Nishikawa, M, "Bisphosphonates act on osteoblastic cells and inhibit osteoclast formation in mouse marrow cultures" 18 : 9-14, 1996

      19 Khosla, S, "Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research" 22 : 1479-1491, 2007

      20 Park-Wyllie, L. Y, "Bisphosphonate use and the risk of subtrochanteric or femoral shaft fractures in older women" 305 (305): 783-789, 2011

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2016-03-10 학술지명변경 외국어명 : Korean Journal of Oriental Physiology & Pathology -> Journal of Physiology & Pathology in Korean Medicine KCI등재
      2016-02-24 학회명변경 한글명 : 대한동의병리학회 -> 한의병리학회
      영문명 : The Korean Society Of Oriental Pathology -> The Society of Pathology in Korean Medicine
      KCI등재
      2013-01-01 평가 등재 1차 FAIL (등재유지) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2007-09-03 학술지명변경 외국어명 : Korean Journal of Oriental Medical Pathology -> Korean Journal of Oriental Physiology & Pathology KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2003-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2002-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2000-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.47 0.47 0.41
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.35 0.33 0.485 0.09
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