When Thoughts Are in a Race: Area 10 and Bipolar Disorders

다국어 초록 (Multilingual Abstract)

Racing thought, when patients incessantly shift from one word or sentence to another while pending previous ones unfinished, is a symptom of (hypo)mania in bipolar disorders received less attention hitherto. Here, based on few evidence, we aim to unfold our hypothetical viewpoint that the frontopolar cortex that is believed to play a part in multitasking and management of competing goals might be dysfunctional in bipolar patients and may contribute in induction of flight of ideas. We then address new avenues for future research and try to encourage researchers to design more comprehensive studies to either accept or decline this proposed conjecture.

목차 (Table of Contents)

• VIEWPOINT AND HYPOTHESIS SCENARIO EVIDENCE TO RELY ON? FUTURE AGENDA

참고문헌 (Reference)

1 Roca M, "The role of Area 10(BA10)in human multitasking and in social cognition : a lesion study" 49 : 3525-3231, 2011

2 Burgess PW, "The gateway hypothesis of rostral prefrontal cortex(area 10)function" 11 : 290-298, 2007

3 Schneider MR, "The effects of carbamazepine on prefrontal activation in manic youth with bipolar disorder" 223 : 268-270, 2014

4 Oyebode F, "Sims’ Symptoms in the Mind: Textbook of Descriptive Psychopathology" Sauners/Elsevier 139-158, 2015

5 Kaladjian A, "Reduced brain activation in euthymic bipolar patients during response inhibition : an event-related fMRI study" 173 : 45-51, 2009

6 Malhi GS, "Mixed mood: the not so united states?" 19 : 242-245, 2017

7 Mansouri FA, "Managing competing goals-a key role for the frontopolar cortex" 18 : 645-657, 2017

8 Ward T, "Encyclopedia of Autism Spectrum Disorders" Springer 1299-1300, 2013

9 Dreher JC, "Damage to the frontopolar cortex is associated with impaired multitasking" 3 : e3227-, 2008

10 Vieta E, "Bipolar disorders" 4 : 18008-, 2018

11 Koechlin E, "Anterior prefrontal function and the limits of human decision-making" 318 : 594-598, 2007

12 Arjmand S, "A brain on a roller coaster: can the dopamine reward system act as a protagonist to subdue the ups and downs of bipolar disorder?" 24 : 423-439, 2018