목적: 신부전은 다발성 골수종에서 종종 발생하며 나쁜 예후를 보인다. 아시아의 다발성 골수종의 발생빈도와 특징은 서양과는 다른 것으로 알려져 있다. 이 연구의 목적은 다발성 골수종 ...
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https://www.riss.kr/link?id=A99916288
2014
-
500
KCI등재후보
학술저널
190-197(8쪽)
0
0
상세조회0
다운로드국문 초록 (Abstract)
목적: 신부전은 다발성 골수종에서 종종 발생하며 나쁜 예후를 보인다. 아시아의 다발성 골수종의 발생빈도와 특징은 서양과는 다른 것으로 알려져 있다. 이 연구의 목적은 다발성 골수종 ...
목적: 신부전은 다발성 골수종에서 종종 발생하며 나쁜 예후를 보인다. 아시아의 다발성 골수종의 발생빈도와 특징은 서양과는 다른 것으로 알려져 있다. 이 연구의 목적은 다발성 골수종 환자들에서 신부전 발생의 위험인자 및 치료 후 신기능 회복 인자를 찾고자 하였다. 방법: 2005년부터 2008년까지 처음 다발성 골수종을 진단 받은 환자를 대상으로 하여 신부전의 발생과 관련된 인자를 조사하였고, 12주간의 치료 후에 신부전의 회복과 관련된 인자를 찾았다. 결과: 진단 당시 221명의 환자 중 86명(39%)에서 신부전이 발생하였다. 이변량 로지스틱 회기 분석에서 낮은 헤모글로빈(OR = 0.813, p = 0.02), 높은 베타-2 마이크로글로불린(OR = 1.006, p < 0.01), ACEi (OR = 2.783, p = 0.04) 사용이 신부전 발생의 독립적인 위험인자로 나타났다. 12주간의 치료 후, 86명 중에서 25 (29%)명의 신기능이 회복되었다. 항암치료에 반응을 보인 경우(OR = 6.044, p < 0.01)와 높은 eGFR (OR = 1.084, p < 0.01)이 회복과 연관된 인자로 나타 났다. 결론: 헤모글로빈 수치, 베타-2 마이크로글로불린, ACEi의 사용이 한국 다발성 골수종 환자에 있어 신부전 발생의 독립적인 위험인자이며 항암 치료에 반응여부와 진단 시의 eGFR이 신기능 회복의 예측인자이다.
다국어 초록 (Multilingual Abstract)
Background/Aims: Multiple myeloma (MM) is frequently accompanied by renal insufficiency, which has been regarded as a poor prognostic factor for MM. It is known that the incidence and characteristics of MM in Asia differ from those in Western countrie...
Background/Aims: Multiple myeloma (MM) is frequently accompanied by renal insufficiency, which has been regarded as a poor prognostic factor for MM. It is known that the incidence and characteristics of MM in Asia differ from those in Western countries. The aim of this study was to evaluate risk factors for renal impairment and to investigate reversible factors for renal failure in patients with MM. Methods: Patients newly diagnosed with MM from 2005 to 2008 were included. We investigated factors associated with renal insufficiency and those related to recovery from renal dysfunction after 12 weeks of treatment of MM. Results: Renal failure was recognized in 86 (39%) of 221 patients at diagnosis. In the binary logistic regression analysis, low hemoglobin (odds ratio [OR], 0.813; p = 0.02), high β2microglobulin (OR, 1.006; p < 0.01), and use of angiotensin-converting enzyme inhibitors (ACEi) (OR, 2.783; p < 0.04) at initial presentation were independent risk factors for renal failure in patients with multiple myeloma. After 12 weeks of treatment, 25 of 86 (29%) patients with renal failure had recovered renal function. Good response to chemotherapy (OR, 6.044; p < 0.01) and higher eGFR (OR, 1.084; p < 0.01) were associated with renal function recovery. Conclusions: Levels of hemoglobin and β2microglobulin, and use of ACEi were independent risk factors for the development of renal failure in MM patients. The response to chemotherapy and eGFR at diagnosis significantly influenced recovery of renal function. (Korean J Med 2014;86:190-197)
참고문헌 (Reference)
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2 Hutchison CA, "Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis" 4 : 745-754, 2009
3 Dimopoulos MA, "The role of novel agents on the reversibility of renal impairment in newly diagnosed symptomatic patients with multiple myeloma" 27 : 423-429, 2013
4 Oehrlein K, "Successful treatment of patients with multiple myeloma and impaired renal function with lenalidomide: results of 4 German centers" 12 : 191-196, 2012
5 Gupta D, "Role of plasmapheresis in the management of myeloma kidney: a systematic review" 14 : 355-363, 2010
6 Kastritis E, "Reversibility of renal failure in newly diagnosed multiple myeloma patients treated with high dose dexamethasonecontaining regimens and the impact of novel agents" 92 : 546-549, 2007
7 Knudsen LM, "Renal failure in multiple myeloma: reversibility and impact on the prognosis: Nordic Myeloma Study Group" 65 : 175-181, 2000
8 Eleutherakis-Papaiakovou V, "Renal failure in multiple myeloma: incidence, correlations, and prognostic significance" 48 : 337-341, 2007
9 Uchida M, "Renal dysfunction in multiple myeloma" 34 : 364-370, 1995
10 Dimopoulos MA, "Pathogenesis and treatment of renal failure in multiple myeloma" 22 : 1485-1493, 2008
1 Roussou M, "Treatment of patients with multiple myeloma complicated by renal failure with bortezomib-based regimens" 49 : 890-895, 2008
2 Hutchison CA, "Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis" 4 : 745-754, 2009
3 Dimopoulos MA, "The role of novel agents on the reversibility of renal impairment in newly diagnosed symptomatic patients with multiple myeloma" 27 : 423-429, 2013
4 Oehrlein K, "Successful treatment of patients with multiple myeloma and impaired renal function with lenalidomide: results of 4 German centers" 12 : 191-196, 2012
5 Gupta D, "Role of plasmapheresis in the management of myeloma kidney: a systematic review" 14 : 355-363, 2010
6 Kastritis E, "Reversibility of renal failure in newly diagnosed multiple myeloma patients treated with high dose dexamethasonecontaining regimens and the impact of novel agents" 92 : 546-549, 2007
7 Knudsen LM, "Renal failure in multiple myeloma: reversibility and impact on the prognosis: Nordic Myeloma Study Group" 65 : 175-181, 2000
8 Eleutherakis-Papaiakovou V, "Renal failure in multiple myeloma: incidence, correlations, and prognostic significance" 48 : 337-341, 2007
9 Uchida M, "Renal dysfunction in multiple myeloma" 34 : 364-370, 1995
10 Dimopoulos MA, "Pathogenesis and treatment of renal failure in multiple myeloma" 22 : 1485-1493, 2008
11 Blade J, "Nonsecretory myeloma, immunoglobulin D myeloma, and plasma cell leukemia" 13 : 1259-1272, 1999
12 Lee JH, "Multiple myeloma in Korea: past, present, and future perspectives: experience of the Korean Multiple Myeloma Working Party" 92 : 52-57, 2010
13 Goldschmidt H, "Multiple myeloma and renal failure" 15 : 301-304, 2000
14 Korbet SM, "Multiple myeloma" 17 : 2533-2545, 2006
15 Heher EC, "Kidney disease associated with plasma cell dyscrasias" 116 : 1397-1404, 2010
16 Durie BG, "International uniform response criteria for multiple myeloma" 20 : 1467-1473, 2006
17 Kim MK, "Immunoglobulin D multiple myeloma: response to therapy, survival, and prognostic factors in 75 patients" 22 : 411-416, 2011
18 Markowitz GS, "Dysproteinemia and the kidney" 11 : 49-63, 2004
19 International Myeloma Working Group, "Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group" 121 : 749-757, 2003
20 Kim SJ, "Clinical features and survival outcomes in patients with multiple myeloma: analysis of web-based data from the Korean Myeloma Registry" 122 : 200-210, 2009
21 Jemal A, "Cancer statistics, 2009" 59 : 225-249, 2009
22 Rabb H, "Acute renal failure from multiple myeloma precipitated by ACE inhibitors" 33 : E5-, 1999
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증례 : 내분비-대사 ; 그레이브스병에서 메티마졸 투여 후 발생한 무과립구증과 급성충수염
증례 : 신장 ; 신 이식 후 항체 매개성 거부반응 환자에서 지연성 회복을 보인 치료 1예
증례 : 혈액종양 ; 동종이식으로 치료한 급성 골수성 백혈병 항암 치료 후 골수 무형성증 1예
증례 : 혈액종양 ; 류마티스관절염이 동반된 고전형 카포시육종의 에토포사이드 치료 1예
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 계속평가 신청대상 (계속평가) | |
2021-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | |
2018-12-01 | 평가 | 등재후보 탈락 (계속평가) | |
2017-12-01 | 평가 | 등재후보로 하락 (계속평가) | |
2013-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2010-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2008-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2006-05-15 | 학술지명변경 | 외국어명 : Korean Journal of Medicine -> The Korean Journal of Medicine | |
2006-01-01 | 평가 | 등재학술지 유지 (등재유지) | |
2003-01-01 | 평가 | 등재학술지 선정 (등재후보2차) | |
2002-01-01 | 평가 | 등재후보 1차 PASS (등재후보1차) | |
2000-07-01 | 평가 | 등재후보학술지 선정 (신규평가) |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 0.1 | 0.1 | 0.1 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
0.11 | 0.1 | 0.259 | 0.02 |