The prostaglandins are a group of local tissue hormone with various biological activities that involve almost every organ system.
An attempt was made to clarify the effects of prostaglandin F_(2α) on the catecholamine contents in the uterine and sto...
The prostaglandins are a group of local tissue hormone with various biological activities that involve almost every organ system.
An attempt was made to clarify the effects of prostaglandin F_(2α) on the catecholamine contents in the uterine and stomach tissue of mature female albino rabbits weighing approximately 2.0 ㎏.
Group Ⅰ was normal control group.
Group Ⅱ was treated with 100㎍/㎏ of prostaglandin F_(2α).
Group Ⅲ was preconditioned with 5000μ/㎏ of estrogen and treated with 100㎍/㎏ of prostaglandin F_(2α).
Catecholamine content was determined by Shore and Olin method.
The results obtained were as follow:
1.The catecholamine content in the normal uterine tissue was 0.33±0.06㎍/gm. The catecholamine content in the uterine tissue was greater than that in the stomach tissue.
2. In the prostaglandin F_(2α) treated group, the catecholamine content in the uterine tissue was 1.26±0.54㎍/gm, while that in the stomach tissue was 0.33±0.02㎍/gm. It showed that the catecholamine content in the uterine and stomach tissue were significantly increased by administration of prostaglandin F_(2α).
3. In the estrogen preconditioned prostaglandin F_(2α) treated group, the catecholamine content in the uterine tissue was 0.32±0.12㎍/gm, while that in the stomach tissue was 0.14±0.07㎍/gm. It showed that the catecholamine content in the stomach tissue was increased to compare with the normal control group.
4. The catecholamine content in the uterine tissue showed a marked increase in the prostaglandin F_(2α) treated group, while there was no change in the estrogen preconditioned prostaglandin F_(2α) treated group.
5. The catecholamine contents in the stomach tissue showed a marked increase in the prostaglandin F_(2α) treated group and the estrogen preconditioned prostaglandin F_(2α) treated group.