인슐린비의존형 당뇨병 환자에서 인슐린 분비능력이 당질 및 지질대사에 미치는 영향 = Effects of Insulin Secretion on Glucose and Lipid Metabolism in Korean

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Background: Many studies have shown that obesity is closely related to non-insulin-dependent diabeties mellitus (NIDDM). This study was conducted to manifest the capacity of insulin secretion in Korean. Method: Fasting blood glucose and insulin level were measured in nondiabetic subjects and NIDDM patients. Overweight-obese subjects were divided into 3 groups; normal glucose tolerant, impaired glucose tolerant and NIDDM. Blood gIucose, insulin concentration, serum lipid and lipoprotein profiles were measured for all subjects. Result: In overweight-obese patients, fasting glucose level increased progressively from 70 to 150 mg/dl while plasma insulin concentration showed a 2 5 time in- crease. Shortly after when fasting glucose exceeded 150 mg/dl plsma insulin concentration precipitated and when the glucose level reached 260 mg/dl, they secreted an amount of insulin that is similar to that in healthy nondiabetic individual. The relationship between the response area of plasma insulin and fasting blood glucose was similar. The percent ideal body weight was not significantly different within each group, but waist to hip ratio of the NIDDM groups was higher than control. Overweight-obese NIDDM subjects with fasting glucose more than 150 mg/dl, showed a decreased insulin response area and similar glucose response area compared with the normal weight NIDDM patients. The progression from normal to glucose intolerance and NIDDM was associated with increase in free fatty acid area, Serum triglyceride level was high in overweightobese NIDDM patients, lipid profiles was apparently better in the normal glucose tolerant subjects. Conclusion: The result showed that overweight-obese Korean NIDDM patients were hyperinsulinemic. Insulin resistance represented the initial disturbance in NIDDM and the chronic hyperglycemic state eventually led impaired insulin secretion. NIDDM patients with normal weight had a lower insulin secretion compared with overweight-obese, and poor goucose control increased serum lipid profiles of the patients. From the result we can suggest that well controlled diabetes can minimize the impairment of p-cell function and may both augment insulin secretion and improve lipid metabolism.