Properties and bioavailability assessment of shrimp astaxanthin loaded liposomes

다국어 초록 (Multilingual Abstract)

This study aimed to investigate the effects ofphospholipid composition on the properties and bioavailabilityof astaxanthin-loaded liposomes using cell culture.
Two mixtures of phospholipids with different proportionsof phosphatidylcholine (PC, 23% and 70%) were used atvarious concentrations (0.8, 1.6, and 2.0% w/v) to prepareastaxanthin-loaded liposomes, which were investigated forentrapment efficiency (EE), antioxidant activity, morphologyand changes in astaxanthin properties during a storageperiod of 8 weeks at 4 C. Furthermore, Caco-2 humancolon adenocarcinoma cells were employed to examine thecellular uptake of astaxanthin-loaded liposomes. Thehighest EE was observed with astaxanthin-loaded liposomescontaining 70% PC, and used at the concentration of2.0% w/v. Liposomes maintained the antioxidant activityof astaxanthin. All liposomal preparations were non-toxic.
Cellular uptake of astaxanthin-loaded liposomes containing70% PC was significantly higher than that of 23% PCcontainingliposomes (p\0.05).

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