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      KCI등재 SCOPUS SCIE

      백서에서 난소절제술 후 여성호르몬투여가 방광에 미치는 영향 = The Effects of Estrogen on Detrusor Contraction and the Expression of Muscarinic Receptors in Ovariectomized Rats

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      https://www.riss.kr/link?id=A104590286

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      다국어 초록 (Multilingual Abstract)

      Purpose: The purpose of this study was to evaluate the effects of estrogen on detrusor contraction and the expression of muscarinic receptors in ovariectomized rats.
      Materials and Methods: 24 Sprague-Dawley female virgin rats(12 weeks old) were separated into three groups of 8 rats each. Group I served as a control group, group II was the ovariectomized only rats(Ovx group) and Group III was given estradiol benzoate(0.8mg/kg/day) subcutaneously for 7 consecutive days, beginning 1 week after ovariectomy(Ovx+E group). At the end of the experimental period, each rat was sacrificed and the urinary bladder was removed for contractile studies. The expressions of M2 and M3 receptors in the bladder epithelium and the muscle layer were investigated by performing immunofluorescent staining.
      Results: The Ovx group showed a significantly decreased bladder contractile function on the KCl and carbachol-induced contractile tests, whereas the Ovx+E group showed increased contractility(p<0.05). The Ovx+E group showed an increase of smooth muscle compared to the other groups. Ovariectomy induced a significant increase in the M3 receptors density in the bladder body, as compared to the control group(p<0.05) but there was no significant difference between the Ovx group and the Ovx+E group.
      Conclusions: Bladder dysfunction of menopausal women is thought not to be related with the changes of muscarinic receptors. Our results suggest that the detrusor contractility of menopausal women might be improved after estrogen replacement therapy.
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      Purpose: The purpose of this study was to evaluate the effects of estrogen on detrusor contraction and the expression of muscarinic receptors in ovariectomized rats. Materials and Methods: 24 Sprague-Dawley female virgin rats(12 weeks old) were separa...

      Purpose: The purpose of this study was to evaluate the effects of estrogen on detrusor contraction and the expression of muscarinic receptors in ovariectomized rats.
      Materials and Methods: 24 Sprague-Dawley female virgin rats(12 weeks old) were separated into three groups of 8 rats each. Group I served as a control group, group II was the ovariectomized only rats(Ovx group) and Group III was given estradiol benzoate(0.8mg/kg/day) subcutaneously for 7 consecutive days, beginning 1 week after ovariectomy(Ovx+E group). At the end of the experimental period, each rat was sacrificed and the urinary bladder was removed for contractile studies. The expressions of M2 and M3 receptors in the bladder epithelium and the muscle layer were investigated by performing immunofluorescent staining.
      Results: The Ovx group showed a significantly decreased bladder contractile function on the KCl and carbachol-induced contractile tests, whereas the Ovx+E group showed increased contractility(p<0.05). The Ovx+E group showed an increase of smooth muscle compared to the other groups. Ovariectomy induced a significant increase in the M3 receptors density in the bladder body, as compared to the control group(p<0.05) but there was no significant difference between the Ovx group and the Ovx+E group.
      Conclusions: Bladder dysfunction of menopausal women is thought not to be related with the changes of muscarinic receptors. Our results suggest that the detrusor contractility of menopausal women might be improved after estrogen replacement therapy.

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      다국어 초록 (Multilingual Abstract)

      Purpose: The purpose of this study was to evaluate the effects of estrogen on detrusor contraction and the expression of muscarinic receptors in ovariectomized rats.
      Materials and Methods: 24 Sprague-Dawley female virgin rats(12 weeks old) were separated into three groups of 8 rats each. Group I served as a control group, group II was the ovariectomized only rats(Ovx group) and Group III was given estradiol benzoate(0.8mg/kg/day) subcutaneously for 7 consecutive days, beginning 1 week after ovariectomy(Ovx+E group). At the end of the experimental period, each rat was sacrificed and the urinary bladder was removed for contractile studies. The expressions of M2 and M3 receptors in the bladder epithelium and the muscle layer were investigated by performing immunofluorescent staining.
      Results: The Ovx group showed a significantly decreased bladder contractile function on the KCl and carbachol-induced contractile tests, whereas the Ovx+E group showed increased contractility(p<0.05). The Ovx+E group showed an increase of smooth muscle compared to the other groups. Ovariectomy induced a significant increase in the M3 receptors density in the bladder body, as compared to the control group(p<0.05) but there was no significant difference between the Ovx group and the Ovx+E group.
      Conclusions: Bladder dysfunction of menopausal women is thought not to be related with the changes of muscarinic receptors. Our results suggest that the detrusor contractility of menopausal women might be improved after estrogen replacement therapy.
      번역하기

      Purpose: The purpose of this study was to evaluate the effects of estrogen on detrusor contraction and the expression of muscarinic receptors in ovariectomized rats. Materials and Methods: 24 Sprague-Dawley female virgin rats(12 weeks old) were separ...

      Purpose: The purpose of this study was to evaluate the effects of estrogen on detrusor contraction and the expression of muscarinic receptors in ovariectomized rats.
      Materials and Methods: 24 Sprague-Dawley female virgin rats(12 weeks old) were separated into three groups of 8 rats each. Group I served as a control group, group II was the ovariectomized only rats(Ovx group) and Group III was given estradiol benzoate(0.8mg/kg/day) subcutaneously for 7 consecutive days, beginning 1 week after ovariectomy(Ovx+E group). At the end of the experimental period, each rat was sacrificed and the urinary bladder was removed for contractile studies. The expressions of M2 and M3 receptors in the bladder epithelium and the muscle layer were investigated by performing immunofluorescent staining.
      Results: The Ovx group showed a significantly decreased bladder contractile function on the KCl and carbachol-induced contractile tests, whereas the Ovx+E group showed increased contractility(p<0.05). The Ovx+E group showed an increase of smooth muscle compared to the other groups. Ovariectomy induced a significant increase in the M3 receptors density in the bladder body, as compared to the control group(p<0.05) but there was no significant difference between the Ovx group and the Ovx+E group.
      Conclusions: Bladder dysfunction of menopausal women is thought not to be related with the changes of muscarinic receptors. Our results suggest that the detrusor contractility of menopausal women might be improved after estrogen replacement therapy.

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      참고문헌 (Reference)

      1 Zullo MA, "Vaginal estrogen therapy and overactive bladder symptoms in postmenopausal patients after a tension-free vaginal tape procedure: a randomized clinical trial" 12 : 421-427, 2005

      2 Keane DP, "Urinary incontinence: anatomy, physiology and pathophysiology" 14 : 207-226, 2000

      3 Liang W, "The influence of ovariectomy and estrogen replacement on voiding patterns and detrusor muscarinic receptor affinity in the rat" 71 : 351-362, 2002

      4 Palea S, "The effect of ovariectomy on the contractile response of the rat isolated detrusor muscle and urethra" 61 : PL21-PL26, 1997

      5 Fleischmann N, "The effect of ovariectomy and long-term estrogen replacement on bladder structure and function in the rat" 168 : 1265-1268, 2002

      6 Aikawa K, "The effect of ovariectomy and estradiol on rabbit bladder smooth muscle contraction and morphology" 170 : 634-637, 2003

      7 Juan YS, "The effect of low-dose estrogen therapy on ovariectomized female rabbit bladder" 71 : 1209-1213, 2008

      8 Zhu Q, "Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents" 166 : 1136-1141, 2001

      9 Longhurst PA, "Pharmacological techniques for the in vitro study of the urinary bladder" 45 : 91-108, 2001

      10 Wang P, "Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins" 273 : 959-966, 1995

      1 Zullo MA, "Vaginal estrogen therapy and overactive bladder symptoms in postmenopausal patients after a tension-free vaginal tape procedure: a randomized clinical trial" 12 : 421-427, 2005

      2 Keane DP, "Urinary incontinence: anatomy, physiology and pathophysiology" 14 : 207-226, 2000

      3 Liang W, "The influence of ovariectomy and estrogen replacement on voiding patterns and detrusor muscarinic receptor affinity in the rat" 71 : 351-362, 2002

      4 Palea S, "The effect of ovariectomy on the contractile response of the rat isolated detrusor muscle and urethra" 61 : PL21-PL26, 1997

      5 Fleischmann N, "The effect of ovariectomy and long-term estrogen replacement on bladder structure and function in the rat" 168 : 1265-1268, 2002

      6 Aikawa K, "The effect of ovariectomy and estradiol on rabbit bladder smooth muscle contraction and morphology" 170 : 634-637, 2003

      7 Juan YS, "The effect of low-dose estrogen therapy on ovariectomized female rabbit bladder" 71 : 1209-1213, 2008

      8 Zhu Q, "Role of ovarian hormones in the pathogenesis of impaired detrusor contractility: evidence in ovariectomized rodents" 166 : 1136-1141, 2001

      9 Longhurst PA, "Pharmacological techniques for the in vitro study of the urinary bladder" 45 : 91-108, 2001

      10 Wang P, "Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins" 273 : 959-966, 1995

      11 Matsui M, "Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype" 97 : 9579-9584, 2000

      12 Stengel PW, "M2 and M4 receptor knockout mice: muscarinic receptor function in cardiac and smooth muscle in vitro" 292 : 877-885, 2000

      13 Blacher J, "Long-term cardiovascular effects of high "osteoprotective" dose levels of 17-beta estradiol in spontaneously hypertensive rats" 14 : 303-307, 2000

      14 Simunic V, "Local estrogen treatment in patients with urogenital symptoms" 82 : 187-197, 2003

      15 Longhurst PA, "Leggett RE, Levin RM. The influence of ovariectomy and estradiol replacement on urinary bladder function in rats" 148 : 915-919, 1992

      16 Levin RM, "Estrogen-induced alterations in the autonomic responses of the rabbit urinary bladder" 215 : 614-618, 1980

      17 Lin AD, "Estrogen induces angiogenesis of the female rabbit bladder" 190 : 241-246, 2006

      18 Lin AD, "Estrogen induced functional hypertrophy and increased force generation of the female rabbit bladder" 25 : 473-479, 2006

      19 Matsumoto M, "Effects of long-term estradiol treatment on the contractile response to muscarine and muscarinic receptor subtypes in the bladder of aged female rats" 28 : 309-314, 2008

      20 Parekh MH, "Effects of castration on female rabbit bladder physiology and morphology" 64 : 1048-1051, 2004

      21 Shapiro E, "Effect of estrogens on the weight and muscarinic cholinergic receptor density of the rabbit bladder and urethra" 135 : 1084-1087, 1986

      22 Susset JG, "Collagen in 155 human bladders" 16 : 204-206, 1978

      23 Longhurst PA, "Characterization of the functional muscarinic receptors in the rat urinary bladder" 116 : 2279-2285, 1995

      24 Tsai E, "Bladder neck circulation by Doppler ultrasonography in postmenopausal women with urinary stress incontinence" 98 : 52-56, 2001

      25 Diep N, "Age dependent response to exogenous estrogen on micturition, contractility and cholinergic receptors of the rat bladder" 64 : 279-289, 1999

      26 Andersson KE, "Advances in the pharmacological control of the bladder" 84 : 195-213, 1999

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      2016-03-04 학술지명변경 외국어명 : 미등록 -> Investigative and Clinical Urology KCI등재
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      2009-02-21 학술지명변경 한글명 : 대한비뇨기과학회지 -> Korean Journal of Urology
      외국어명 : The Korean Journal of Urology -> 미등록
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      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.14 0.14 0.13
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.13 0.12 0.314 0.23
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