전신홍반루푸스 환자에서 미코페놀레이트모페틸 음독 후 발생한 심실성빈맥 = Mycophenolate Mofetil Overdose Induced Ventricular Tachycardia in a Patient with Systemic Lupus Erythematosus

국문 초록 (Abstract)

MMF의 과량 복용 후 발생한 심혈관계 부작용은 아직까지 보고된 바 없었다. 저자들은 구조적 심장 질환이 없는 SLE 환자에서 34 g의 MMF를 음독 후 발생한 심실성빈맥 1예를 경험하였기에 문헌고찰과 함께 보고한다.

다국어 초록 (Multilingual Abstract)

Mycophenolate mofetil (MMF) is an immunosuppressive agent used to treat severe lupus, including lupus nephritis. Common adverse effects of MMF include gastrointestinal and hematological manifestations; however, cardiac toxicity in association with MMF has not been reported. We present a 21-year-old woman with lupus nephritis who developed ventricular tachycardia 2 hours after an overdose of MMF (34 g). Ventricular bigeminy was documented 12 hours after the MMF overdose. Transthoracic echocardiography showed no evidence of structural heart disease. The ventricular arrhythmia was successfully treated with potassium replacement, hydration, and cholestyramine. This case suggests that an overdose of MMF can induce ventricular tachycardia, and electrocardiogram monitoring is critical to identify this rare cardiac complication of MMF. (Korean J Med 2019;94:455-458)