H_1 및 H_2 수용체 차단제가 피부 히스타민반응에 미치는 영향 = The Effect of H_1 and H_2 Blockade on Cutaneous Histamine Response in Man

다국어 초록 (Multilingual Abstract)

Histamine-induced cutaneous wheal responses were measured in 24 healthy subjects. The effect of the potent H_1 blocker, hydroxyzine HCI, the H_2 blocker, cimetidine, and the two drugs in combination was determined. The H_1 blocker alone produced a mean wheal suppression of 77%(p<0.005). The H_2 blocker alone produced a mean wheal suppression of 35%(p<0.01). The H_1 plus H_2 blocker produced 79% suppression. But the augmented suppression of H_1 plus H_2 blocker vs H_1 blocker was not statistically significant (p>0.05). The result provide evidence that H_2 receptors are present in the human cutaneous blood vessel, but additional studies must be performed to determine the significance of combined H_1 and H_2 blockade over H_1 blocker alone in suppression of histamine-induced wheal formation.