본 연구팀에서는 방사선으로부터 위장관과 면역조혈계를 방호하기 위하여 당귀, 천궁, 백작약으로 새로운 생약복합물 HIM-I을 개발하였고, HIM-I을 에탄올 침전하여 에탄올 분획(HIM-I-E)과 조다...
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https://www.riss.kr/link?id=A76301978
2006
Korean
KCI등재,SCOPUS
학술저널
1127-1132(6쪽)
6
0
상세조회0
다운로드국문 초록 (Abstract)
본 연구팀에서는 방사선으로부터 위장관과 면역조혈계를 방호하기 위하여 당귀, 천궁, 백작약으로 새로운 생약복합물 HIM-I을 개발하였고, HIM-I을 에탄올 침전하여 에탄올 분획(HIM-I-E)과 조다...
본 연구팀에서는 방사선으로부터 위장관과 면역조혈계를 방호하기 위하여 당귀, 천궁, 백작약으로 새로운 생약복합물 HIM-I을 개발하였고, HIM-I을 에탄올 침전하여 에탄올 분획(HIM-I-E)과 조다당 분획(HIM-I-P)을 얻은 후, HIM-I에 조다당 분획을 첨가하여 HemoHIM을 제조하여 실험하였으며, 과산화수소를 이용하여 산화적 스트레스를 유발한 후 HemoHIM의 apoptosis 억제 효과를 측정하였다. 과산화수소를 세포주에 처리한 결과 세포독성 증가, 세포막 파괴, subG1기 세포 증가, DNA 절단 현상 등이 관찰되었다. 이때 HIM-I, HIM-I-P, HemoHIM을 첨가하여 전처리 배양한 다음에 과산화수소로 apoptosis를 유도하였다. 그 결과 과산화수소에 의한 세포독성, 세포막 파괴, subG1기 세포, DNA 절단현상 등이 현저하게 감소하는 것으로 나타났다. 전반적으로 HemoHIM의 방호 효과는 HIM-I-P와 비슷하였으며 HIM-I보다 높은 것으로 나타났다. 이상의 결과로 HemoHIM은 면역기능 방호?회복 물질로서 뿐만 아니라 산화적 스트레스에 대한 항산화제로서 유용하게 활용될 수 있을 것으로 생각된다.
다국어 초록 (Multilingual Abstract)
In our previous study, a novel herb mixture (HIM-I) of Angelica gigas radix, Cnidium officinale rhizoma, and Paeonia japonica radix was developed to protect the intestinal and immune systems and promote its recovery against radiation damage. A new her...
In our previous study, a novel herb mixture (HIM-I) of Angelica gigas radix, Cnidium officinale rhizoma, and Paeonia japonica radix was developed to protect the intestinal and immune systems and promote its recovery against radiation damage. A new herbal composition (HemoHIM) with the high immune modulating activity was developed from HIM-I. HIM-I was fractionated into ethanol fraction (HIM-I-E) and polysaccharide fraction (HIM-I-P). And HemoHIM was prepared by adding HIM-I-P to HIM-I. HemoHIM showed more effective than HIM-I in immune modulation as well as radioprotection. The present study is designed to investigate the protective effects of HIM-I, HIM-I-P, and HemoHIM on hydrogen peroxide (H₂O₂)-induced apoptosis of human promyelocytic leukemia (HL-60) cells. It was shown that H₂O₂ treatment reduced the viability of cells, and increased appearance of DNA ladders, hypodiploid (subG1) cells, and phosphatidylserine translocation level. Pretreatment of HemoHIM significantly reduced the cytotoxic effect induced by H₂O₂, associated with reducing the translocation of phosphatidylserine, hypodiploid cells and DNA ladders. HemoHIM appeared to be more protective than HIM-I against H₂O₂-induced apoptosis whereas, it exhibited similar activity to HIM-I-P. These results indicated that HemoHIM might be an useful agent for protection against oxidative stress (H₂O₂)-induced apoptosis as well as immune modulation, especially since it is a relatively nontoxic natural product.
참고문헌 (Reference)
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1 "The role of proteases during apoptosis" 10 : 587-597, 1996
2 "The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive." 234 : 185-193, 2002
3 "The radioprotective effects of radices herbs" 41 : 105-111, 2001
4 "The radioprotective effects of Bu- Zhong-Yi-Qi-Tang A prescription of traditional Chinese medicine" 30 : 127-137, 2002
5 "The radioprotective effect of Kuei-Pi- Tang as a prescription of traditional Chinese medicine in mice" 28 : 698-704, 1999
6 "The effects of herbs on the radiation-induced apoptosis in intestinal crypt cells" 26 : 27-33, 2001
7 "The effects of Shi-Quan-Dai-Bu-Tang and its ingredients on the survival of jejunal crypt cells and hematopoietic cells in irradiated mice" 29 : 93-98, 2000
8 "The control of apoptosis in mammalian cells" 307-309, 1993
9 "Structurally related antitumor effects of flavanones in vitro and in vivo: involvement of caspase 3 activation p21 gene expression, and reactive oxygen species production." 197 : 84-95, 2004
10 "Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids" 66 : 1139-1150, 2003
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13 "Protective effects of Paeonia japonica against radiation-induced damage" 27 : 181-188, 2002
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참나물이 고콜레스테롤식이를 섭취한 흰쥐의 지질대사에 미치는 영향
Genistein과 Daidzein 급여가 제2형 당뇨동물모델의 적혈구와 조직 중의 항산화방어계에 미치는 영향
학술지 이력
연월일 | 이력구분 | 이력상세 | 등재구분 |
---|---|---|---|
2023 | 평가예정 | 해외DB학술지평가 신청대상 (해외등재 학술지 평가) | |
2020-01-01 | 평가 | 등재학술지 유지 (해외등재 학술지 평가) | ![]() |
2014-06-24 | 학회명변경 | 한글명 : 한국식품영양과학회지 -> 한국식품영양과학회영문명 : Journal of the Korean Society of Food Science and Nutrition -> The Korean Society of Food Science and Nutrition | ![]() |
2014-04-02 | 학회명변경 | 한글명 : 한국식품영양과학회 -> 한국식품영양과학회지영문명 : 미등록 -> Journal of the Korean Society of Food Science and Nutrition | ![]() |
2011-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2009-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2007-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2005-01-01 | 평가 | 등재학술지 유지 (등재유지) | ![]() |
2002-07-01 | 평가 | 등재학술지 선정 (등재후보2차) | ![]() |
2000-01-01 | 평가 | 등재후보학술지 선정 (신규평가) | ![]() |
학술지 인용정보
기준연도 | WOS-KCI 통합IF(2년) | KCIF(2년) | KCIF(3년) |
---|---|---|---|
2016 | 1.03 | 1.03 | 1.13 |
KCIF(4년) | KCIF(5년) | 중심성지수(3년) | 즉시성지수 |
1.18 | 1.2 | 1.993 | 0.21 |