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      Differential Growth of the Reproductive Organs during the Peripubertal Period in Male Rats

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      https://www.riss.kr/link?id=A104165121

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      다국어 초록 (Multilingual Abstract)

      In mammals, puberty is a process of acquiring reproductive competence, triggering by activation of hypothalamic kisspeptin (KiSS)-gonadotropin releasing hormone (GnRH) neuronal circuit. During peripubertal period, not only the external genitalia but the internal reproductive organs have to be matured in response to the hormonal signals from hypothalamic-pituitary-gonadal (H-P-G) axis. In the present study, we evaluated the maturation of male rat accessory sex organs during the peripubertal period using tissue weight measurement, histological analysis and RT-PCR assay. Male rats were sacrificed at 25, 30, 35, 40, 45, 50, and 70 postnatal days (PND). The rat accessory sex organs exhibited differential growth patterns compared to those of non-reproductive organs. The growth rate of the accessory sex organs were much higher than the those of non-reproductive organs. Also, the growth spurts occurred differentially even among the accessory sex organs; the order of prepubertal organ growth spurts is testis = epididymis > seminal vesicle = prostate. Histological study revealed that the presence of sperms in seminiferous tubules and epididymal ducts at day 50, indicating the puberty onset. The number of duct and the volume of duct in epididymis and prostate were inversely correlated during the experimental period. Our RT-PCR revealed that the levels of hypothalamic GnRH transcript were increased significantly on PND 40, suggesting the activation of hypothalamic GnRH pulse-generator before puberty onset. Studies on the peripubertal male accessory sex organs will provide useful references on the growth regulation mechanism which is differentially regulated during the period in androgen-sensitive organs. The detailed references will render easier development of endocrine disruption assay.
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      In mammals, puberty is a process of acquiring reproductive competence, triggering by activation of hypothalamic kisspeptin (KiSS)-gonadotropin releasing hormone (GnRH) neuronal circuit. During peripubertal period, not only the external genitalia but t...

      In mammals, puberty is a process of acquiring reproductive competence, triggering by activation of hypothalamic kisspeptin (KiSS)-gonadotropin releasing hormone (GnRH) neuronal circuit. During peripubertal period, not only the external genitalia but the internal reproductive organs have to be matured in response to the hormonal signals from hypothalamic-pituitary-gonadal (H-P-G) axis. In the present study, we evaluated the maturation of male rat accessory sex organs during the peripubertal period using tissue weight measurement, histological analysis and RT-PCR assay. Male rats were sacrificed at 25, 30, 35, 40, 45, 50, and 70 postnatal days (PND). The rat accessory sex organs exhibited differential growth patterns compared to those of non-reproductive organs. The growth rate of the accessory sex organs were much higher than the those of non-reproductive organs. Also, the growth spurts occurred differentially even among the accessory sex organs; the order of prepubertal organ growth spurts is testis = epididymis > seminal vesicle = prostate. Histological study revealed that the presence of sperms in seminiferous tubules and epididymal ducts at day 50, indicating the puberty onset. The number of duct and the volume of duct in epididymis and prostate were inversely correlated during the experimental period. Our RT-PCR revealed that the levels of hypothalamic GnRH transcript were increased significantly on PND 40, suggesting the activation of hypothalamic GnRH pulse-generator before puberty onset. Studies on the peripubertal male accessory sex organs will provide useful references on the growth regulation mechanism which is differentially regulated during the period in androgen-sensitive organs. The detailed references will render easier development of endocrine disruption assay.

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      참고문헌 (Reference)

      1 Dart DA, "Visualising androgen receptor activity in male and female mice" 8 (8): e71694-, 2013

      2 Vomachka AJ, "The development of gonadotropin and steroid hormone patterns in male and female hamsters from birth to puberty" 105 (105): 960-966, 1979

      3 Rivest RW, "Sexual maturation in female rats: hereditary, developmental and environmental aspects" 47 (47): 1027-1038, 1991

      4 Wheeler MD, "Physical changes of puberty" 20 (20): 1-14, 1991

      5 Navarro VM, "Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin" 8 (8): 11-20, 2007

      6 Okahashi N, "Lack of evidence for endocrine disrupting effects in rats exposed to fenitrothion in utero and from weaning to maturation" 206 (206): 17-31, 2005

      7 Blystone CR, "Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production" 174 (174): 74-81, 2007

      8 van Weissenbruch MM, "Fetal nutrition and timing of puberty" 8 : 15-33, 2005

      9 Rossi R, "Evidence for androgen receptor gene expression and growth inhibitory effect of dihydrotestosterone on human adrenocortical cells" 159 (159): 373-380, 1998

      10 Kim HS, "Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide" 67 (67): 52-62, 2002

      1 Dart DA, "Visualising androgen receptor activity in male and female mice" 8 (8): e71694-, 2013

      2 Vomachka AJ, "The development of gonadotropin and steroid hormone patterns in male and female hamsters from birth to puberty" 105 (105): 960-966, 1979

      3 Rivest RW, "Sexual maturation in female rats: hereditary, developmental and environmental aspects" 47 (47): 1027-1038, 1991

      4 Wheeler MD, "Physical changes of puberty" 20 (20): 1-14, 1991

      5 Navarro VM, "Neuroendocrine factors in the initiation of puberty: the emergent role of kisspeptin" 8 (8): 11-20, 2007

      6 Okahashi N, "Lack of evidence for endocrine disrupting effects in rats exposed to fenitrothion in utero and from weaning to maturation" 206 (206): 17-31, 2005

      7 Blystone CR, "Iprodione delays male rat pubertal development, reduces serum testosterone levels, and decreases ex vivo testicular testosterone production" 174 (174): 74-81, 2007

      8 van Weissenbruch MM, "Fetal nutrition and timing of puberty" 8 : 15-33, 2005

      9 Rossi R, "Evidence for androgen receptor gene expression and growth inhibitory effect of dihydrotestosterone on human adrenocortical cells" 159 (159): 373-380, 1998

      10 Kim HS, "Evaluation of the 20-day pubertal female assay in Sprague-Dawley rats treated with DES, tamoxifen, testosterone, and flutamide" 67 (67): 52-62, 2002

      11 Sakabe K, "Effects of sex steroids on the proliferation of thymic epithelial cells in a culture model: a role of protein kinase C" 72 (72): 193-199, 1994

      12 Navarro VM, "Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide" 145 (145): 4565-4574, 2004

      13 Nishino T, "Androgen-dependent morphology of prostates and seminal vesicles in the Hershberger assay: evaluation of immunohistochemical and morphometric parameters" 186 (186): 247-253, 2004

      14 Stefani S, "Androgen responsiveness and androgen receptor gene expression in human kidney cells in continuous culture" 32 (32): 597-604, 1994

      15 Yadav N, "Androgen action in the prostate gland" 64 (64): 35-49, 2012

      16 Macleod DJ, "Androgen action in the masculinization programming window and development of male reproductive organs" 33 (33): 279-287, 2010

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2027 평가예정 재인증평가 신청대상 (재인증)
      2021-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2018-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2015-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2011-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2010-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2009-01-01 평가 등재후보학술지 유지 (등재후보2차) KCI등재후보
      2008-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      2007-01-01 평가 등재후보학술지 유지 (등재후보1차) KCI등재후보
      2005-01-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.4 0.4 0.32
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.27 0.25 0.394 0.13
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