The Effects of Vascular Endothelial Growth Factor on Capsule Formation around Silicone Implant in Rats

다국어 초록 (Multilingual Abstract)

Background The purpose of this study was to examine the effects of a single administration of vascular endothelial growth factor (VEGF) in promoting the angiogenesis and thereby reducing the formation of capsular contracture.
Methods We treated 24 female Sprague-Dawley rats with (1) 5 mM Tris Buffer and 150 mM NaCl 0.1 cc, (2) VEGF 15 μg/0.1 cc, (3) VEGF 150 μg/0.1 cc during placement of the implant, or (4) VEGF 150 μg/0.1 cc and VEGF 300 μg/0.2 cc. We histopathologically measured the thickness of the capsule and the number of blood vessels.
Results All experimental groups had a significant difference in the thickness of the capsule compared to the control group (P<0.001). There was no significant difference between experimental group 2 and experimental group 3. The number of blood vessels formed around the capsule was significantly greater in all the experimental groups compared with the control group (P<0.05). There was no significant difference between the experimental groups. There was a significant negative correlation between the thickness of the capsule and the number of blood vessels (Spearman’s correlation coefficient, 0.2732; P<0.0001).
Conclusions A single administration of VEGF reduced formation of the capsule and increased the vascularity around the implant, supporting the hypothesis that prevention of tissue ischemia can be a treatment strategy for capsular contracture.

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