국내 유통 중인 음료식품과 속쓰림과의 관련성에 관한 연구 = The Relationship between the Popular Beverages in Korea and Reported Postprandial Heartburn

다국어 초록 (Multilingual Abstract)

Background/Aims: The aim of this study was to investigate the frequency of heartburn produced by beverages available in Korea and to clarify the mechanism causing heartburn. Methods: We measured pH, titratable acidity, and osmolality of 35 beverages in vitro and correlated them with the severity of heartburn reported by questionnaire in 382 patients from November 2004 to June 2005. Results: Coffee (1.15) and soju (1.12) showed the highest heartburn score, while oolong tea (0.17) and carrot juice (0.18) showed the lowest heartburn score among all beverages. Titratable acidity of citrus juices correlated with heartburn (r=0.78; p=0.023). Soft drinks had the lowest pH, which was unrelated with heartburn scores (r=?0.54; p=0.460). Increasing pH among alcoholic beverages was correlated with heartburn scores (r=0.84; p=0.037), and osmolality was inversely associated with heartburn scores (r=?0.86; p=0.028). The heartburn score of decaffeinated coffee was significantly lower than that of regular coffee (p＜0.001). Regular milk caused more heartburn than low-fat milk (p=0.008). Conclusions: Our findings provide dietary information that helps to select appropriate beverages to the patients with heartburn. (Korean J Gastroenterol 2010;55:109-118)

참고문헌 (Reference)

1 Boekema PJ, "van Berge Henegouwen GP, Smout AJPM. Coffee and gastrointestinal function: facts and fiction" 34 : S35-S39, 1999

2 Decarli A, "Vitamin A and other dietary factors in the etiology of esophageal cancer" 10 : 29-37, 1987

3 Kim YB, "The incidence of gastroesophageal reflux disease and the effect of cisapride in patients with epigastric soreness" 6 : 188-195, 2000

4 Bujanda L, "The effects of alcohol consumption upon the gastrointestinal tract" 95 : 3374-3382, 2000

5 Pehl C, "The effect of decaffeination of coffee on gastro-oesophageal reflux in patients with reflux disease" 11 : 483-486, 1997

6 Klauser AG, "Symptoms in gastro-oesophageal reflux disease" 335 : 205-208, 1990

7 Cuomo R, "Sweetened carbonated drinks do not alter upper digestive tract physiology in healthy subjects" 20 : 780-789, 2008

8 McArthur K, "Relative stimulatory effects of commonly ingested beverages on gastric acid secretion in humans" 83 : 199-203, 1982

9 Feldman M, "Relationships between the acidity and osmolality of popular beverages and reported postprandial heartburn" 108 : 125-131, 1995

10 Chow HH, "Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals" 9 : 3312-3319, 2003

11 Salaspuro M, "Interrelationship between alcohol, smoking, acetaldehyde and cancer" 285 : 80-89, 2007

12 Lloyd DA, "Food-induced heartburn: effect of osmolality" 80 : 740-741, 1981

13 Schiller LR, "Distention-induced gastrin release: effects of luminal acidification and intravenous atropine" 78 : 912-917, 1980

14 Kahrilas PJ, "Cigarette smoking and gastroesophageal reflux disease" 10 : 61-71, 1992

15 Edelstein ZR, "Central adiposity and risk of Barrett's esophagus" 133 : 403-411, 2007

16 Ibiebele TI, "Cancers of the esophagus and carbonated beverage consumption: a population-based case-control study" 19 : 577-584, 2008

17 Ligumsky M, "Antioxidants inhibit ethanol-induced gastric injury in the rat. Role of manganese, glycine, and carotene" 30 : 854-860, 1995

18 Woo IS, "An improved method for determination of ethyl carbamate in Korean traditional rice wine" 26 : 363-368, 2001

19 Chari S, "Alcohol and gastric acid secretion in humans" 34 : 843-847, 1993

20 Cranley JP, "Abnormal lower esophageal sphincter pressure responses in patients with orange juice-induced heartburn" 81 : 104-106, 1986