HBsAg 과 Anti - HBs 가 모두 양성인 바이러스성 간질환 환자의 아형에 관한 연구 = A Study on the Subtype of Patients with Concomitant Hepatitis B Surface Antigen and Anti - bodyHBsAg 과 Anti - HBs 가 모두 양성인 바이러스성 간질환 환자의 아형에 관한 연구

다국어 초록 (Multilingual Abstract)

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다국어 초록 (Multilingual Abstract)

Since the presence of concomitant hepatitis B surface antigen and anti-body has been reported by Koziol et al, in blood donors the concomitancy has been evaluated by means of subtyping of HBsAg and anti-HBs. The subtype of HBsAg and/or anti-HBs was essayed through radioimmunoassay in 46 patients with concomitant hepatitis B surface antigen and antibody, and 19 patients with HBsAg positive but anti-HBs negative. The following results were obtained. 1) The concomitant HBsAg/anti-HBs positivity was seen in 18,9% of HBsAg positive patients. 2) In the most of concomitant cases (16.0%), the pattern was indicative of HBsAg/ad in the presence anti-ay, non-neutralized antibody. 3) The ad subtype of HBsAg in control group and concomitant group were 94.7%, 84.8%, respectively. And among 46 cases of concomitant group, the subtype of anti-HBs was anti-ay in 39 (84.7%). 4) No significant correlation was noted between the subtypes found and severity of the clinical disease. 5) In concomitant subjects. the mean S/N ratio of HBsAg was 73.9±25.3 and positive rate of HBeAg was 71,7%. In patients with HBsAg(+)/anti-HBs (-), the mean S/N ratio of HBsAg as 79.7±10.5 and positive rate of HBsAg was 78.9%, and there was no significant statistical significance between concomitant group and control group. In conclusion, the majority of subtype of HBsAg was ad in Korea and the most common pattern of subtypes in concomitant cases was ad in HBsAg and anti-ay in anti-HBs. In concomitant cases, there were various patterns of clinical entity and serologic profiles and it may provide a clue to lack of complete protection against HBV in some persons after earlier HBV infection.