Oral lipid based multiparticulate pastilles: design and effect of pore former

다국어 초록 (Multilingual Abstract)

The purpose of this research work was todesign and develop droplet solidification apparatus for lipidbased pastilles. Oral lipid based multiparticulate pastillesof solid lipid glycerol monostearate were formulated tocontrol the release of highly water soluble drug metoprololsuccinate. The apparatus was optimized at 14G needle sizeand metallic surface base plate cooled at 4 ˚C. Pastilleswere evaluated for their size, shape, contact angle, density,flow properties, friability, crushing strength, drug content,thermal properties, in vitro and in vivo drug release. Pastilleswere hemispherical in shape of size 3.1–4.3 mm.
Contact angle was found to be more than 120˚. Drugrelease was controlled for 8 h. Scanning electron microscopystudy revealed the smooth external surface with poresto ingress dissolution media to enhance the drug releaserate. Increased quantity of pore former enhanced the dissolutionrate. Other operating variables like contact angleand height of needle from base plate were found to affectthe size of pastilles. The dissolution of optimized batch ofpastilles was best fitted to first order kinetic model. In vivopharmacokinetic study showed correlation with in vitrodrug release profile.

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