인공모델막에 대한 polyene 계 항생물질의 영향 ( 1 ) = Effects of Polyene Antibiotics on Multilamellar Liposomes ( 1 )

다국어 초록 (Multilingual Abstract)

The interaction of polyene antibiotics, amphotericin B and nystatin, with liposomes has been investigated. The activity of amphotericin B and nystatin as a function of cholesterol and ergosterol contents was studied. The polyene were added at approximate final molarities of 10^(-6)-10^(-4)M. The molar percentage of sterols was increased from 0 ㏖% to 50 ㏖%. At this concentration range, nystatin had very little effect and amphotericin B had a little stronger effect. At a higher concentration above 8×10^(-5)M, amphotericin B showed strong lytic activity on liposomes with or without sterols. These studies suggest that amphotericin B is more potent lytic agent than nystatin and that the affinites for sterols of two polyene antibiotics depend strongly on their concentrations and sterol contents.