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      지충이 에탄올 추출물의 α-amylase 저해활성 = Inhibitory Effects of Sargassum thunbergii Ethanol Extract against α-amylase

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      https://www.riss.kr/link?id=A103871753

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      다국어 초록 (Multilingual Abstract)

      This study was performed to investigate the inhibitory activity of Sargassum thunbergii (ST) against α-amylase and elucidate the availability of ST extract as a functional food agent. To test the inhibitory activity of ST against α-amylase, porcine pancreatic α-amylase and potato starch were used as substrates. It was revealed that ST crude ethanol extracts have high α-amylase inhibitory activity. Subsequently, ST crude ethanol extract was separated into five partition layers by solvent extraction: n-hexane, chloroform, ethyl acetate, butanol, and water. Chloroform and n-hexane fractions showed higher inhibitory activities than did acarbose (positive control). To confirm the changes in enzyme inhibitory activity by physical treatments, ST crude ethanol extract was subjected to heat, pH, and γ-irradiation treatments. In all heat treatments with the exception of one (121℃, 15 min), the inhibitory activity was increased compared with the untreated group. With regard to pH stability, ST extract showed no significant changes at pH 4–6, but somewhat decreased inhibitory activity was revealed at pH 2, 8, and 10. On the other hand, ST ethanol extract was stable under γ-irradiation under all conditions (3–20 kGy). In summary, ST ethanol extract can be used in the food industry as a natural α-amylase inhibitor.
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      This study was performed to investigate the inhibitory activity of Sargassum thunbergii (ST) against α-amylase and elucidate the availability of ST extract as a functional food agent. To test the inhibitory activity of ST against α-amylase, porcine ...

      This study was performed to investigate the inhibitory activity of Sargassum thunbergii (ST) against α-amylase and elucidate the availability of ST extract as a functional food agent. To test the inhibitory activity of ST against α-amylase, porcine pancreatic α-amylase and potato starch were used as substrates. It was revealed that ST crude ethanol extracts have high α-amylase inhibitory activity. Subsequently, ST crude ethanol extract was separated into five partition layers by solvent extraction: n-hexane, chloroform, ethyl acetate, butanol, and water. Chloroform and n-hexane fractions showed higher inhibitory activities than did acarbose (positive control). To confirm the changes in enzyme inhibitory activity by physical treatments, ST crude ethanol extract was subjected to heat, pH, and γ-irradiation treatments. In all heat treatments with the exception of one (121℃, 15 min), the inhibitory activity was increased compared with the untreated group. With regard to pH stability, ST extract showed no significant changes at pH 4–6, but somewhat decreased inhibitory activity was revealed at pH 2, 8, and 10. On the other hand, ST ethanol extract was stable under γ-irradiation under all conditions (3–20 kGy). In summary, ST ethanol extract can be used in the food industry as a natural α-amylase inhibitor.

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      참고문헌 (Reference)

      1 김균하, "추출용매 변화에 따른 바나바(Lagerstroemia speciosa Pers.) 잎 추출물의 항당뇨 효과" 한국생명과학회 18 (18): 1305-1311, 2008

      2 변명우, "추출방법과 감마선 조사에 따른 귤피 추출물 생리활성의 변화" 한국식품저장유통학회 10 (10): 388-393, 2003

      3 이소영, "지충이(Sargassum thunbergii) 에탄올 추출물의 항균활성" 한국식품영양과학회 38 (38): 502-508, 2009

      4 이소정, "지충이 추출물의 항산화, 항균 활성 및 물리적 특성에 미치는 감마선 조사의 영향" 한국식품과학회 42 (42): 431-437, 2010

      5 성낙주, "지충이 용매 추출물의 항산화 활성" 한국식품영양과학회 35 (35): 139-144, 2006

      6 이보배, "제비꽃 추출물의 항산화 활성 및 α-Amylase와 α-Glucosidase에 대한 저해 활성" 한국식품영양과학회 37 (37): 405-409, 2008

      7 김정환, "산사(Crataegi Fructus) 추출물로부터 α-amylase와α-glucosidase 저해 물질 분리 및 동정" 한국응용생명화학회 50 (50): 204-209, 2007

      8 최혜정, "사방오리나무 추출물의 α-amylase 및 α-glucosidase 저해활성" 한국생명과학회 18 (18): 1005-1010, 2008

      9 김희정, "비파 메탄올 추출물의 생리활성 및 방사선 조사 효과" 한국식품과학회 38 (38): 684-690, 2006

      10 최혜정, "번행초 추출물의 당뇨관련 효소에 관한 저해 활성" 한국생물공학회 23 (23): 419-424, 2008

      1 김균하, "추출용매 변화에 따른 바나바(Lagerstroemia speciosa Pers.) 잎 추출물의 항당뇨 효과" 한국생명과학회 18 (18): 1305-1311, 2008

      2 변명우, "추출방법과 감마선 조사에 따른 귤피 추출물 생리활성의 변화" 한국식품저장유통학회 10 (10): 388-393, 2003

      3 이소영, "지충이(Sargassum thunbergii) 에탄올 추출물의 항균활성" 한국식품영양과학회 38 (38): 502-508, 2009

      4 이소정, "지충이 추출물의 항산화, 항균 활성 및 물리적 특성에 미치는 감마선 조사의 영향" 한국식품과학회 42 (42): 431-437, 2010

      5 성낙주, "지충이 용매 추출물의 항산화 활성" 한국식품영양과학회 35 (35): 139-144, 2006

      6 이보배, "제비꽃 추출물의 항산화 활성 및 α-Amylase와 α-Glucosidase에 대한 저해 활성" 한국식품영양과학회 37 (37): 405-409, 2008

      7 김정환, "산사(Crataegi Fructus) 추출물로부터 α-amylase와α-glucosidase 저해 물질 분리 및 동정" 한국응용생명화학회 50 (50): 204-209, 2007

      8 최혜정, "사방오리나무 추출물의 α-amylase 및 α-glucosidase 저해활성" 한국생명과학회 18 (18): 1005-1010, 2008

      9 김희정, "비파 메탄올 추출물의 생리활성 및 방사선 조사 효과" 한국식품과학회 38 (38): 684-690, 2006

      10 최혜정, "번행초 추출물의 당뇨관련 효소에 관한 저해 활성" 한국생물공학회 23 (23): 419-424, 2008

      11 임채성, "말채나무 추출물의 α-amylase 저해 활성" 한국응용생명화학회 48 (48): 103-108, 2005

      12 조성희, "당뇨 생쥐에서 대황 추출물 및 정제환의 혈당과 지질 상태 개선 효과" 한국영양학회 41 (41): 493-501, 2008

      13 Gao H, "α-Glucosidase inhibition of 6-hydroxyflavone s. Part 3: synthesis and evaluation of 2,3,4-trihydroxybenzoyl-containing flavonoid analogs and 6-aminoflavones as α-glucosidase inhibitors" 13 : 1661-1671, 2005

      14 Lee SH, "α-Glucosidase and α-amylase inhibitory activities of phloroglucinal derivatives from edible marine brown alga, Ecklonia cava" 89 : 1552-1558, 2009

      15 Ali H, "α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus" 107 : 449-455, 2006

      16 Moon JS, "The physicochemical properties of α-amylase inhibitors from black bean and naked barley in Korea" 37 : 367-375, 1998

      17 Swain T, "The phenolic constituents of Prunus domestica. I-The quantitative analysis of phenolic constituents" 10 : 63-68, 1959

      18 Hara Y, "The inhibition of α-amylase by tea polyphenols" 54 : 1939-1945, 1990

      19 Bitou N, "Screening of lipase inhibitors from marine algae" 34 : 441-445, 1999

      20 Granum PE, "Purification and characterization of an amylase inhibitor from rye (Secale cerale) flour" 2 : 103-120, 1978

      21 Yang F, "Preparation of polysaccharide derived from Sargassum thunbergii and its antioxidant activity" 26 : 224-227, 2005

      22 Puls W, "Influence of α-amylase inhibitor (BAY D7791) on blood-glucose, serum- insulin and NEFA in starch loading test in rats, dogs and man" 9 : 97-101, 1973

      23 Choi Y, "Influence of heat treatment on the antioxidant activities and polyphenolic compounds of shiitake (Lentinus edodes) mushroom" 99 : 381-387, 2006

      24 Kim HY, "In vitro inhibitory activity on rat intestinal mucosa α-glucosidase by rice hull extract" 29 : 601-608, 1997

      25 Yook HS, "Effects of gamma irradiation on microbial decontamination, extraction yields and physiological effectiveness of Korean medicinal plants" 30 : 581-589, 1998

      26 Mulimani VH, "Effect of heat treatment and germination on alpha amylase inhibitor activity in chick peas (Cicer arietinum L.)" 46 : 133-137, 1994

      27 Ha JK, "Effect of buffers and alfalfa hay on ruminal and systemic parameters of sheep fed high concentrate diets" 27 : 80-96, 1985

      28 McLaughlin CL, "Effect of acarbose on acute acidosis" 92 : 2758-2766, 2009

      29 Heo SJ, "Diphlorethohydroxy carmalol isolated from Ishige okamurae, a brown algae, a potent α-glucosidase and α-amylase inhibitor, alleviates postprandial hyperglycemia in diabetic mice" 615 : 252-256, 2009

      30 Kageyama S, "Comparison of the effects of acarbose and voglibose in healthy subjects" 19 : 720-729, 1997

      31 Mahmud T, "Biosynthetic studies on the α-glucosidase inhibitor acarbose in Actinoplanes sp.; 2-epi-5-epi-valiolone is the direct precursor of the valienamine moiety" 121 : 6973-6983, 1999

      32 Ryu BH, "Antitumor activity of seaweeds agar on Sarcoma-180" 21 : 595-600, 1989

      33 Iwai K, "Antidiabetic and antioxidant effects of polyphenols in brown alga Ecklonia stolonifera in genetically diabetic KK-Ay mice" 65 : 163-169, 2008

      34 Baht M, "Antidiabetic Indian plats : a good source of potent amylase inhibitors" eCAM 1-6, 2008

      35 김미선, "100종 네팔 식물 추출물로부터 α-Amylase 및 α-Glucosidase저해제의 선별" 한국미생물·생명공학회 38 (38): 183-189, 2010

      36 Chrzaszcz T, ""Sisto-amylase", a natural inhibitor of amylase" 27 : 3491-3505, 1933

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      학술지 이력

      학술지 이력
      연월일 이력구분 이력상세 등재구분
      2026 평가예정 재인증평가 신청대상 (재인증)
      2020-01-01 평가 등재학술지 유지 (재인증) KCI등재
      2017-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2014-08-06 학술지명변경 외국어명 : Korean Journal of Fisheries and Aquatic Sciences -> Korean Journal of Fisheries and Aquatic Sciences KCI등재
      2013-01-01 평가 등재학술지 유지 (계속평가) KCI등재
      2010-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2009-09-04 학회명변경 한글명 : 한국수산학회 -> 한국수산과학회
      영문명 : The Korean Fisheries Society -> The Korean Society of Fisheries and Aquatic Science
      KCI등재
      2009-07-03 학술지명변경 한글명 : 한국수산학회지 -> 한국수산과학회지
      외국어명 : Journal of The Korean Fisheries Society -> Korean Journal of Fisheries and Aquatic Sciences
      KCI등재
      2008-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2006-01-01 평가 등재학술지 유지 (등재유지) KCI등재
      2003-01-01 평가 등재학술지 선정 (등재후보2차) KCI등재
      2002-01-01 평가 등재후보 1차 PASS (등재후보1차) KCI등재후보
      1999-07-01 평가 등재후보학술지 선정 (신규평가) KCI등재후보
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      학술지 인용정보

      학술지 인용정보
      기준연도 WOS-KCI 통합IF(2년) KCIF(2년) KCIF(3년)
      2016 0.47 0.47 0.43
      KCIF(4년) KCIF(5년) 중심성지수(3년) 즉시성지수
      0.43 0.43 0.59 0.17
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