급성 Virus 성 간염 환자에서 고속액체 Chromatography 를 이용한 혈청 담즙산의 분석 = Bile Acid Analysis by High-performance Liquid Chromatography in the Patients with Acute Viral Hepatitis

다국어 초록 (Multilingual Abstract)

The physiologic status of enterhepatic bile flow is changed in hepatobiliary tracts and gastroenteric disorders. Recently it is reported as a diagnostic tool in liver diseases to check a serum bile acid level.
We have checked serum total bile acid level and its 15 fractions in 13 cases of control group and 5 cases of acute viral hepatitis group by high-performance liquid chromatography.
The results were as follows:
1) In control group, serum total bile acid levels at the fasting, and postprandial 1 and 2 hours were 10.39±3.15, 13.91±2.58, 12.71±3.27 mmol/L (mean±SD), respectively.
In the levels of 15 fractions of serum total pile acid at the fasting, and postprandial 1 and 2 hours, deoxycholic acid were 2.89±1.51, 3.74±1.42, 3,43±2.26 mmol/L, glycocholic acid 1.16±0.5, l.80±0.58, l.23±0.56 mmol/L in the order of concentration.
2) In acute viral hepatitis group, serum total bile acid levels at the fasting and postprandial 2 hours were 80.78±2.25, 93.76±20.56 mmol/L, In the levels of 15 fractions of serum total bile acid, glycochenodeoxycholic acid were 31.58±11.11, 37.94±7.00 mmol/L, glycocholic acid 16.50±3.18, 21.27±6.03 mmol/L, taurochenodeoxycholic acid 15.44±8.50, 15.38±5.94 mmol/L, ursodeoxycholic acid 7.61±2.47, 6.86±2.21 mmol/L in the order of concentration.
Cholic acid was 4.9, glycocholic acid 17.2, chenoxycholic acid 3.1, glycochenodeoxycholic acid 31.6, taurochendeoxycholi acid 13.9, and tauroursodeoxycholic acid 8, 1 times higher in acute viral hepatitis group than those of control group.