Purple grape juice supplementation in smokers and antioxidant status according to different types of <i>GST </i> polymorphisms

다국어 초록 (Multilingual Abstract)

<P>DNA damages and antioxidant status was assessed after 8 weeks of purple grape juice supplementation in male smokers depending on the glutathione <I>S</I>-transferase polymorphisms. Ninety-five smokers consumed 480 ml of purple grape juice for 8 weeks. The blood samples were collected before and after supplementation to measure lymphocyte DNA damages, plasma antioxidants, conjugated diene, and the erythrocyte antioxidant enzymes. The diastolic pressure, lymphocyte DNA damage, and plasma conjugated diene were significantly decreased but the plasma γ-tocopherol was increased in <I>GSTM1</I>-null genotype, while increased blood glutathione and decreased lymphocyte DNA damage were observed in <I>GSTM1</I>-present genotype. In case of <I>GSTT1</I> on the other hand, the decrease in diastolic pressure and lymphocyte DNA damage was observed in both null types and present types, but the erythrocyte catalase activity was decreased in <I>GSTT1</I>-null type and the plasma vitamin C level was increased in <I>GSTT1</I>-present type, suggesting that, the antioxidant effect of grape juice was greater in <I>GSTT1</I>-present type compared to <I>GSTT1</I>-null type. The intakes of 8-week purple grape juice affected diastolic blood pressures, DNA damage reductions and antioxidant status in smokers, mainly greater in <I>GSTM1</I>-null type and <I>GSTT1</I>-present type.</P>