To determine the effect of picolinic acid on NO· production, murine macrophages were incubated with either medium, various concentrations of picolinic acid, or IFN-γ plus picolinic acid for 48 hr. Picolinic acid does not induce NO· production by it...
To determine the effect of picolinic acid on NO· production, murine macrophages were incubated with either medium, various concentrations of picolinic acid, or IFN-γ plus picolinic acid for 48 hr. Picolinic acid does not induce NO· production by itself, it acted synergistically with INF-γ for the induction of reactive nitrogen intermediate production in murine macrophages. Thymidine incorporation appeared to be reciprocally related to nitrite levels, suggesting that IFN-γ plus picolinic acid induced NO· synthesis exerted antiproliferative effects.