Vascular cell adhesion molecule-1 (VCAM-1) has been implicated in selective eosinophil recruitment characterizing allergicinflammation. To understand the events involved in selective eosinophil migration into allergic inflammatory sites, we performedq...
Vascular cell adhesion molecule-1 (VCAM-1) has been implicated in selective eosinophil recruitment characterizing allergicinflammation. To understand the events involved in selective eosinophil migration into allergic inflammatory sites, we performedquantitative analysis of VCAM-1 mRNA expression levels in the nasal mucosa of TDI-induced allergic rats. Expressionlevels of VCAM-1 mRNA from inferior turbinate were examined using competitive PCR in 35 allergic rats and 5 control ratsand compared with infiltrated eosinophil counts. Quantity of VCAM-1 mRNA was more increased in allergy group than in thecontrol group, especially in group sacrificed 3 hours to 4 days after provocation. Infiltrating eosinophils were correlated with theexpression levels of VCAM-1 mRNA (p<0.01). These results suggest that VCAM-1 plays a predominant role in controllingantigen-induced eosinophil recruitment into the tissue, and that the induction of VCAM-1 expression on the endothelium at thesite of allergic inflammation regulates eosinophil recruitment.