Benzodiazepine이 인후두 역류증에 미치는 영향 = Efficacy of Benzodiazepines to Laryngopharyngeal Reflux：A Double-Blind, Randomized Controlled Study

다국어 초록 (Multilingual Abstract)

Background and Objectives：Anti-anxiety drugs such as benzodiazepines are often given to globus patients in practice, based on the notion that globus is a kind of somatization disorder. However, many of globus are caused by laryngopharyngeal reflux (LPR) and the effects of anti-anxiety drugs to LPR are unknown. The study goal was to assess the efficacy of benzodiazepines to LPR. Subjects and Method：We selected 51 LPR patients, who were confirmed by 24-hour double-probe ambulatory pH monitoring. Patients were allocated into case and control groups at random and entered into a double-blind trial. Patients in the control group received proton pump inhibitors and prokinetics. Diazepam was added to patients in the case group. Assessments were made after 4 weeks of treatment using reflux symptom index (RSI) and reflux finding score (RFS). Results：In both groups, RSI and RFS were improved significantly at the end of the study. However, there was no significant difference between the two groups. Conclusion：Diazepam seems to have little efficacy in the treatment of LPR.

참고문헌 (Reference)

1 "Validity and reliability of thereflux symptom index" 274-7, 2002

2 "The validity and reliability ofthe reflux finding score" 1313-7, 2001

3 "The otolaryngologic manifestations of gastroesophagealreflux disease A clinical investigation of 225 patients usingambulatory 24-hour pH monitoring and an experimental investigationof the role of acid and pepsin in the development of laryngeal injury" 1-78, laryngoscope1991

4 "The effect of intravenousdiazepam on esophageal motility in normal subjects" 36 : 1046-9, Sci1991

5 "Prevalence of reflux in 113 consecutivepatients with laryngeal and voice disorders" 123 : 385-8, 2000

6 "Pharyngoesophageal dysmotility in globus sensation" 115 : 1086-90, 1989

7 "Persistent gastroesophageal reflux disease symptoms onstandard proton-pump inhibitor therapy" 31 : -84, Am2002

8 "Panic disorder associated with gastrointestinal disease:Review and hypotheses" 44 : 91-105, 1998

9 "Life events and difficulties in relationto the onset of globus pharyngis" 40 : 603-15, 1996

10 "Laryngopharyngeal reflux:State of the art diagnosisand treatment" 33 : 785-802, 2000

11 "Globus pharyngeus:Longtermfollow-up and prognostic factors" 100 : 351-4, Laryngol1991

12 "Effect of diazepam on the lower esophagealsphincter.A double-blind controlled study" 73 : 127-30, 1980

13 "Diagnosis oflaryngopharyngeal reflux among globus patients" In press