복분자 열매 추출물의 유용 생리활성 탐색

다국어 초록 (Multilingual Abstract)

The biological activities of extracts from Rubus coreanus Miq. ere compared, About 70% of the growth of human hepatocarcinoma and 79% of human gastric cancer call was inhibited in adding 1.0㎎/ml of the extracts of Rubus coreanus Miq. respectively. The growth of human breast cancer cells was also inhibited in adding 1.0 ㎎/ml of the extracts as well as 78% of the human cancer cells. It was proved that the growth of human normal lung cell, scored as 15% for the extracts. Overall selectivity of the extracts on several human cancer cell line was over 5, which is higher than those from the Rubus coreanus Miq. The growth of both human immune B and T cells was enhanced up to 1.4 to 1.8 times by adding the extracts, compared to the controls. The secretion of tumor necrosis factor-alpha(TNF-α) from T cell was also increased up to 78.8pg/ml in adding the ethanol extract (0.5 ㎎/ml). Ethanol extracts also increased up to about 70 pg/ml of interleukin-6(IL-6) from B cell. For screening regulate function of blood pressure, angiotensin converting enzyme(ACE) activity was inhibited up to 25% by adding ethanol extract (1.0 ㎎/ml). In testing the hypoglycemic activity, 20% of α-glucosidase activity was inhibited for the extracts (0.5 ㎎/ml). GST activity was increased in the range of 1.2 to 1.6 times by adding extracts.