The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial

다국어 초록 (Multilingual Abstract)

Stress, anxiety, and depression, along with feeling overwhelmed and exhausted have been widely reported by college students as factors that negatively impact their academic performance, and overall well-being. Ashwagandha is an Ayurvedic herb that has been used historically to support healthy responses to stressors, but has recently gained popularity in the United States for its ability to support well-being for populations who experience chronic stress. To our knowledge, there have not been any human trials evaluating the efficacy of ashwagandha on stress in the United States. No studies to date have used qualitative research methods to consider the experiential impact of ashwagandha supplementation. Our purpose was to explore the lived experiences of college students participating in a double-blind randomized control trial evaluating the impact of ashwagandha as an intervention to support college students' well-being. Participants were college students (N = 60) age 18–50 years, who were randomized to either intervention or placebo group to take one capsule twice a day for 30 days. Intervention group participants took 700 mg of full spectrum extract of ashwagandha root per day, whereas those in the placebo group took glycerol capsules. Qualitative data included daily affect check-ins and focus groups. Data were analyzed using Dedoose qualitative coding software and thematic analysis. Four themes resulted regarding energy levels, mental clarity, sleep dynamics, and stress. Our findings demonstrated that ashwagandha increased college students' perceived well-being through supporting sustained energy, heightened mental clarity, and enhanced sleep quality, through a moderate dose of ashwagandha for the course of 30 days.
Clinical Trial Registration number: NCT05430685.

참고문헌 (Reference)

1 Selda Koydemir, "Well-being on campus: testing the effectiveness of an online strengths-based intervention for first year college students" Informa UK Limited 44 (44): 434-446, 2015

2 Jack O’Connor ; Keston Lindsay ; Cynthia Baker ; Jessica Kirby ; Andrea Hutchins ; Margaret Harris, "The Impact of Ashwagandha on Stress, Sleep Quality, and Food Cravings in College Students: Quantitative Analysis of a Double-Blind Randomized Control Trial" 한국식품영양과학회 25 (25): 1086-1094, 2022

3 Abhijit Deshpande, "Study protocol and rationale for a prospective, randomized, double-blind, placebo-controlled study to evaluate the effects of Ashwagandha (Withania somnifera) extract on nonrestorative sleep" Ovid Technologies (Wolters Kluwer Health) 97 (97): e11299-, 2018

4 Merriam SB, "Qualitative Research: A Guide to Design and Implementation" John Wiley & Sons 2016

5 Mandy D. Bamber, "Mindfulness-based meditation to decrease stress and anxiety in college students: A narrative synthesis of the research" Elsevier BV 18 : 1-32, 2016

6 Alexander G. Panossian, "Evolution of the adaptogenic concept from traditional use to medical systems: Pharmacology of stress‐ and aging‐related diseases" Wiley 41 (41): 630-703, 2020

7 Arnett JJ, "Emerging Adulthood: The Winding Road from the Late Teens Through the Twenties" Oxford University Press 2014

8 Stéphanie Baggio, "Emerging Adulthood: A Time of Changes in Psychosocial Well-Being" SAGE Publications 40 (40): 383-400, 2016

9 Dnyanraj Choudhary, "Efficacy and safety of ashwagandha (Withania somnifera (L.) dunal) root extract in improving memory and cognitive functions" Informa UK Limited 14 (14): 599-612, 2017

10 Sunil B Kelgane, "Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study" Cureus, Inc. 2020

11 Deepak Langade, "Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study" Cureus, Inc. 2019

12 Alexander Panossian, "Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms Associated with Their Stress—Protective Activity" MDPI AG 3 (3): 188-224, 2010

13 Ronald C Plotnikoff, "Effectiveness of interventions targeting physical activity, nutrition and healthy weight for university and college students: a systematic review and meta-analysis" Springer Science and Business Media LLC 12 (12): 1-10, 2015

14 Usharani Pingali, "Effect of standardized aqueous extract of Withania somniferaon tests of cognitive and psychomotor performance in healthy human participants" EManuscript Technologies 6 (6): 12-, 2014

15 Lattie EG, "Digital mental health interventions for depression, anxiety and enhancement of psychological well-being among college students: Systematic review" 21 (21): e12869-e12869, 2019

16 Tom Deliens, "Dietary interventions among university students: A systematic review" Elsevier BV 105 : 14-26, 2016

17 Dnyanraj Choudhary, "Body Weight Management in Adults Under Chronic Stress Through Treatment With Ashwagandha Root Extract" SAGE Publications 22 (22): 96-106, 2016

18 Adrian L. Lopresti, "Ashwagandha (Withania somnifera) for the treatment and enhancement of mental and physical conditions: A systematic review of human trials" Elsevier BV 28 : 100434-, 2021

19 Baghurst T, "An examination of stress in college students over the course of a semester" 15 (15): 438-447, 2013

20 Morgan A. Pratte, "An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania somnifera)" Mary Ann Liebert Inc 20 (20): 901-908, 2014

21 "American College Health Association National College Health Assessment: Publications and Reports"

22 K. N. Roy Chengappa, "Adjunctive Use of a Standardized Extract of <em>Withania somnifera</em> (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia" Physicians Postgraduate Press, Inc 79 (79): 2018

23 Salve J, "Adaptogenic and anxiolytic effects of ashwagandha root extract in healthy adults : A doubleblind, randomized, placebo-controlled clinical study" e6466-, 2019

24 Friedrich A, "A systematic review of psychological interventions to improve sleep in college students" 27 (27): 4-22, 2018

25 Auddy B, "A standardized Withania somnifera extract significantly reduces stress-related parameters in chronically stressed humans: A double-blind, randomized, placebo-controlled study" 11 (11): 50-56, 2008

26 Singh N, "A rasayana(rejuvenator)of ayurveda" 8 (8): 208-213, 2011

27 K. Chandrasekhar, "A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults" SAGE Publications 34 (34): 255-262, 2012

28 Darren P. Morton, "A Multimodal Intervention for Improving the Mental Health and Emotional Well-being of College Students" SAGE Publications 14 (14): 216-224, 2017