Long-term Synaptic Plasticity: Circuit Perturbation and Stabilization

다국어 초록 (Multilingual Abstract)

At central synapses, activity-dependent synaptic plasticity has a crucial role in information processing,storage, learning, and memory under both physiological and pathological conditions. Onewidely accepted model of learning mechanism and information processing in the brain is HebbianPlasticity: long-term potentiation (LTP) and long-term depression (LTD). LTP and LTD are respectivelyactivity-dependent enhancement and reduction in the efficacy of the synapses, which are rapid andsynapse-specific processes. A number of recent studies have a strong focal point on the criticalimportance of another distinct form of synaptic plasticity, non-Hebbian plasticity. Non-Hebbianplasticity dynamically adjusts synaptic strength to maintain stability. This process may be very slowand occur cell-widely. By putting them all together, this mini review defines an important conceptualdifference between Hebbian and non-Hebbian plasticity.

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